Evidence map›Paper›PMID 41584256›Full record

ArticleJournal of the American College of Emergency Physicians open2026

Starting Up Clinical Trials in Emergency Medicine: Advice and Acronyms for New Investigators.

Lauren T Southerland, Ching-Min B Chu, Henry E Wang, Jennifer Frey, Micheal Hill, Michelle M Nassal, Jason J Bischof

Abstract read
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lauren T SoutherlandDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Ching-Min B ChuDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Henry E WangDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Jennifer FreyDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Micheal HillDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Michelle M NassalDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Jason J BischofDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.

Funding

Artificial Intelligence for Dynamic, individualized CPR guidance: AID CPRK08HL168330 · NHLBI · OHIO STATE UNIVERSITY · PI Michelle M.J. Nassal · 2023 to 2026
$646k
NHLBI NIH HHS K08 HL168330
6 · The paper itself

Abstract

Well-conducted clinical trials are essential to developing our evidence base for medical care. However, the regulatory guidelines and differing operations surrounding clinical trials can be daunting and difficult for new investigators. New investigators often find themselves trying to learn clinical trial management on the go, as this aspect of research is not routinely taught in medical school or residency. To address this problem, this article explains clinical trial startup, including the regulatory and operational aspects of investigator-initiated trials, multicenter trials, and different funding sources (government, foundation, and industry). We also include tables of over 30 common acronyms used in clinical trial operations and discuss common research infrastructure and protocols. The goal of this article is to collate study startup knowledge and materials in one place to build the emergency medicine pipeline of clinical trialists and researchers.

Indexed as

adverse event reportingclinical trialsresearch operationsresearch regulations

Identifiers

PMID41584256
PMCPMC12825047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.