ArticleJournal of oral biology and craniofacial research
Synergistic effects of zinc oxide and ellagic acid on macrophage infiltration, angiogenesis, and collagen deposition in excisional wounds healing.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Objectives: The combination of zinc oxide (ZnO) and ellagic acid (EA) in wound dressings offers synergistic benefits for wound healing due to their complementary antimicrobial, antioxidant, anti-inflammatory, and tissue regenerative properties. This study aimed to evaluate the effects of ZnO-EA dressing on macrophage infiltration, angiogenesis, and collagen density in excisional wounds on days 3 and 7 post-treatment. Materials and methods: This in vivo posttest-only experimental study involved twenty Results: Treatment with ZnO-EA resulted in significant increase in macrophages infiltration, the number of newly formed blood vessels, and collagen density in the treatment group compared to the ZnO group on both days 3 and 7 (p < 0.05). Conclusion: The application of a ZnO wound dressing enriched with EA significantly enhances macrophage infiltration, angiogenesis, and collagen deposition during the wound healing process.
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