ReviewFrontiers in public health2025
Crimean-Congo haemorrhagic fever in pregnancy: clinical outcomes and public health implications.
Review in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of Maternal and Fetal Outcomes of Crimean-Congo Hemorrhagic Fever during Pregnancy.Emerging infectious diseases · 2026Pooled it
- Pathogenicity and virulence of Crimean-Congo hemorrhagic fever virus: From enzootic maintenance to severe human disease.Virulence · 2026Review
- Human exposure to Crimean-Congo hemorrhagic fever virus is associated with livestock management and handling practices in southcentral Tanzania, 2023-2024.BMC infectious diseases · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crimean-Congo haemorrhagic fever (CCHF) is the most widespread tick-borne viral disease of humans, with major public-health implications across western China, South Asia, the Middle East, south-eastern Europe, and Africa. Although uncommon, infection during pregnancy is often severe and associated with high maternal and fetal mortality. This mini review synthesizes 38 documented cases of CCHF in pregnancy to identify consistent patterns in clinical presentation, outcomes, and management. Maternal survival was recorded in 68% of cases, whereas fetal or neonatal survival was reported in only 39%. Ribavirin therapy has been associated with improved maternal outcomes in limited case reports, but its use in pregnancy remains restricted because of teratogenicity. Disease frequently mimicked obstetric emergencies such as HELLP syndrome, delaying diagnosis. CCHF during pregnancy presents substantial diagnostic and therapeutic challenges, including limited antiviral options and heightened risks of nosocomial transmission. Early recognition, timely virological confirmation, and strict infection-control measures are essential. Strengthening obstetric surveillance in endemic regions and developing pregnancy-safe therapeutics remain urgent priorities. Development of pregnancy-safe antivirals and integration of obstetric surveillance into endemic-area health systems are urgently needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.