ReviewRSC advances2026
Engineering combination nanomedicines to overcome cancer resistance.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Biochemical and cellular effects of propolis and silver nanoparticle combination: apoptotic signaling and antibiofilm activity.Molecular biology reports · 2026Article
- Engineering cuproptosis with nanomedicine: Design, combination therapy, and translation in cancer.Materials today. Bio · 2026Review
- Photodynamic Therapy Combined with Anticancer Drug Therapy in the Treatment of Malignant Neoplasms.Cells · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combination nanomedicine enables the coordinated delivery of multiple therapeutic agents using engineered nanosystems to address tumor heterogeneity, multidrug resistance, and systemic toxicity. Despite extensive preclinical progress, many combination nanomedicine strategies fail to translate clinically due to poor pharmacokinetic coordination, limited predictive models, and manufacturing constraints. This review examines design principles for co-delivery platforms based on liposomal, polymeric, inorganic, hybrid, and biomimetic carriers, with attention to pharmacokinetics, biodistribution, endosomal escape, and interactions with the tumor microenvironment. Strategies integrating chemotherapy, immunotherapy, gene- and RNA-based therapies, photodynamic and photothermal modalities, and selected natural compounds are summarized to achieve synergistic therapeutic effects. Stimuli-responsive and actively targeted systems are highlighted for precise release and improved tumor accumulation. Translational progress from preclinical studies to clinical experience, including opportunities and constraints related to manufacturing reproducibility, quality control, immunogenicity, and long-term fate were discussed. Overall, combination nanomedicine shows promise for improving efficacy and safety in cancer therapy, and future work should prioritize modular, clinically scalable platforms, standardized characterization, clinically relevant models, and pathways for scalable production and regulatory evaluation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.