ArticleFrontiers in human neuroscience2025
Impact of sex differences on clinical characteristics of anti-N-methyl-D-aspartate receptor encephalitis during the acute phase: a single-center retrospective study.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To elucidate the influence of sex differences on the clinical characteristics of anti-NMDAR encephalitis during the acute phase. Methods: Patients diagnosed with anti-NMDAR encephalitis who were hospitalized at Huanhu Hospital, affiliated with Tianjin University, from January 2020 to January 2025 were collected. They were divided into two groups: male and female. Clinical data for both groups were gathered, including age, history of prodromal infection, clinical manifestations, complications, presence of tumor, laboratory indices, MRI findings, GCS scores, length of hospital stay, treatment regimens, and acute phase outcomes. Statistical methods were employed to compare the differences between the two groups. Results: A total of 43 patients with anti-NMDAR encephalitis were included in this study, comprising 20 male patients (46.51%) and 23 female patients (53.49%). Female patients were more likely to exhibit decreased levels of consciousness compared to male patients ( Conclusion: Female patients with anti-NMDAR encephalitis experience greater challenges and difficulties compared to male patients. Therefore, it is necessary to choose more proactive treatment options for female patients to help reduce the risk of adverse outcome in acute phase.
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