ArticleStroke (Hoboken, N.J.)2022
Mutation Type and Intracranial Aneurysm Formation in Autosomal Dominant Polycystic Kidney Disease.
Article in Stroke (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Nationwide attribute-based cross-classification reveals distinct risk patterns of major complications in ADPKD.Clinical and experimental nephrology · 2026Article
- Polycystin-1 and Cardiac Remodeling: From Mechanotransduction to Clinical Consequences.Circulation research · 2026Review
- Association of anemia with long-term renal prognosis in autosomal dominant polycystic kidney disease using time-series analysis.Scientific reports · 2026Article
- Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms.Scientific reports · 2025Article
- Stroke in Young Adults: An Overview and Non-Pharmacological Preventive Strategies.Brain sciences · 2025Review
- Visceral fat and attribute-based medicine in chronic kidney disease.Frontiers in endocrinology · 2023Review
- Impact of kidney function and kidney volume on intracranial aneurysms in patients with autosomal dominant polycystic kidney disease.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
Background: Screening for intracranial aneurysms (IAs) in patients with risk factors of IA is recommended. However, genetic risk factors of IA in patients with autosomal dominant polycystic kidney disease (ADPKD) remain unclear, and genotype-phenotype relationships in IAs in patients with ADPKD have not been clarified. Therefore, we aimed to clarify the associations between germline mutations and IA formation in patients with ADPKD. Methods: A total of 135 patients with ADPKD who were evaluated for ADPKD mutations were examined for IA formation in this single-center observational study. Results: The incidence of de novo IA formation was 1.3% per patient-year. Age at IA diagnosis was younger in patients with frameshift (median, 36 years; Conclusions: Genetic analyses in patients with ADPKD could contribute to IA screening and could be useful for evaluating the prognosis, including complications. IA screening should be recommended for patients with ADPKD who have splicing and frameshift mutations and for older patients or patients with advanced ADPKD who have substitutions.
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