ReviewFrontiers in surgery2025
Risk factors for periprosthetic joint infection following primary total knee arthroplasty: a systematic review and meta-analysis.
Review in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Review
- Infection prevention in total knee arthroplasty: current concepts, controversies, and a clinical algorithm.European journal of translational myology · 2026Article
- [Differential analysis of gut microbiome in patients with periprosthetic joint infection, aseptic failure, and osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Periprosthetic joint infection (PJI) represents a severe and devastating complication following primary total knee arthroplasty (TKA), leading to higher morbidity and implant failure. However, existing evidence regarding its risk factors remains inconsistent. Method: PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Chinese Journal Database, and the Chinese Biomedical Literature Service System (SinoMed) were searched for primary studies from the database inception to August 2025. Data were managed with EndNote X9 software, meta-analyses were performed using Review Manager 5.4, infection risk was analyzed using STATA 18, and the comprehensive incidence rate of PJI was analyzed using R 4.5.1. Results: A total of 1,569 studies were identified, of which 20 were included in this systematic review. The meta-analysis including 20 studies analyzed eight risk factors: longer operation time (OR = 9.10, 95% CI: 7.66-10.80), obesity (OR = 13.95, 95% CI: 12.06-16.14), male gender (OR = 2.67, 95% CI: 1.80-3.95), diabetes (OR = 2.98, 95% CI: 2.27-3.92), longer hospital stay (OR = 1.73, 95% CI: 1.38-2.16), use of immunosuppressants (OR = 5.76, 95% CI: 2.77-11.98), hypoalbuminemia (OR = 6.24, 95% CI: 4.00-9.73), and underlying systemic inflammatory disease (OR = 3.47, 95% CI: 1.92-6.27). All identified risk factors were associated with an increased risk of developing PJI after primary TKA. Conclusion: The meta-analysis confirmed that longer operative time, obesity, male gender, diabetes, longer hospital stay, use of immunosuppressants, hypoalbuminemia, and underlying systemic inflammatory disease are risk factors for PJI after primary TKA. This systematic review and meta-analysis provide Level II evidence (according to the Oxford Centre for Evidence-Based Medicine criteria) for the identified risk factors.
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