The Effect of Advances in Pancreatic Cancer Treatment in Population Mortality: A Surveillance, Epidemiology, and End Results-Based Study.

Background and Aims: Pancreatic cancer is a significant health burden with increasing incidence and mortality rates. This study analyzes trends in incidence rates, incidence-based mortality, 2-year survival rates, and disease progression, focusing on gender and racial disparities. Methods: We utilized data from the Surveillance, Epidemiology, and End Results database, covering the period from 2001 to 2019. Incidence rates, incidence-based mortality, and 2-year survival rates were evaluated, with a particular focus on variations across gender and racial groups. Results: The study revealed a higher incidence rate of pancreatic cancer in males compared to females, consistent with previous research. Both genders experienced an upward trajectory in incidence rates. Incidence-based mortality rates also increased for both genders, with higher rates observed in males. Notably, 2-year survival rates improved among most racial groups, except for American Indian/Alaska Natives, where no significant changes were observed. The Black population exhibited the highest incidence rate, followed by White and Asian/Pacific Islanders. The study also highlighted an increase in regional metastatic disease, emphasizing the need for early detection and intervention. Conclusion: The findings underscore the growing burden of pancreatic cancer and the critical need for enhanced early detection and preventive strategies. Disparities in incidence and mortality rates across gender and racial groups were evident, pointing to the necessity of tailored interventions. Improved survival rates in specific populations may be attributed to advances in treatment and the approval of new immunotherapy agents. Future research should focus on optimizing combination therapies and addressing racial disparities to improve outcomes for all pancreatic cancer patients.