Comparison Between In-Hospital and Community-Onset Stroke Treated With Endovascular Thrombectomy: A Propensity Score-Matched Cohort Study.

Background: Patients with acute ischemic stroke onset during hospital admission often have concurrent illnesses, increased underlying comorbidities and are often associated with a delayed recognition of stroke onset, compared with patients with stroke onset in the community (community-onset stroke [COS]). Endovascular thrombectomy (EVT) for large-vessel occlusion in acute ischemic stroke has been proven to be effective, though the safety and feasibility of EVT among patients with in-hospital stroke (IHS) onset remains undetermined. We aim to compare the workflow and clinical outcomes for patients undergoing EVT following IHS onset and COS. Methods: Using data from a national stroke registry, we used propensity score-matched individual-level data of patients who underwent EVT, following IHS and COS, between October 2015 and March 2020. Univariate analysis was performed to assess the procedural, functional, and safety outcomes. Results: We included 4353 patients (COS, 4104 [249 after propensity score matching]; IHS, 249 [249 after propensity score matching]). Compared with COS, patients with IHS had similar modified Rankin Scale on discharge (odds ratio [OR], 0.98 [95% CI, 0.72-1.34]; Conclusions: EVT in patients with IHS is safe and feasible, with comparable functional and safety outcomes to patients with COS, in this national stroke registry. Continued efforts are required to improve the inpatient stroke workflow in recognizing stroke symptoms and initiating reperfusion treatment for eligible patients with IHS.