Evidence map›Paper›PMID 41583675›Full record

ArticleStroke (Hoboken, N.J.)2023

Transradial Versus Transfemoral Access for Mechanical Thrombectomy: A Systematic Review and Meta-Analysis.

Mohamed Elfil, Hazem S Ghaith, Mohamed F Doheim, Pakinam E Aboutaleb, Dominic Romeo, Mohamed M Salem, Mohammad Aladawi, Brian T Jankowitz, Jan-Karl Burkhardt, Thanh N Nguyen and 2 more

Abstract read
In one paragraph

Article in Stroke (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Impact of D-dimer on the outcomes of endovascular thrombectomy for acute ischemic stroke: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Pooled it
  2. Article
  3. Article
  4. Safety and efficacy of using a large bore guide catheter through a short 8-Fr sheath for transradial neurointerventional procedures.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohamed ElfilDepartment of Neurological Sciences University of Nebraska Medical Center Omaha NE.ORCID https://orcid.org/0000-0002-1125-2946
Hazem S GhaithFaculty of Medicine Al-Azhar University Cairo Egypt.
Mohamed F DoheimDepartment of Neurology and Neurosurgery University of Pittsburg Medical Center, UPMC Stroke Institute Pittsburg PA.
Pakinam E AboutalebDepartment of Neurology Penn Medicine Hospital of the University of Pennsylvania Philadelphia PA.
Dominic RomeoDepartment of Neurosurgery Penn Medicine Hospital of the University of Pennsylvania Philadelphia PA.
Mohamed M SalemDepartment of Neurosurgery Penn Medicine Hospital of the University of Pennsylvania Philadelphia PA.
Mohammad AladawiDepartment of Neurological Sciences University of Nebraska Medical Center Omaha NE.
Brian T JankowitzDepartment of Neurosurgery Penn Medicine Hospital of the University of Pennsylvania Philadelphia PA.
Jan-Karl BurkhardtDepartment of Neurosurgery Penn Medicine Hospital of the University of Pennsylvania Philadelphia PA.
Thanh N NguyenDepartment of Neurology Boston University Chobanian and Avedisian School of Medicine Boston MA.
Fawaz Al-MuftiDepartment of Neurosurgery Westchester Medical Center Valhalla NY.
Raul G NogueiraDepartment of Neurology and Neurosurgery University of Pittsburg Medical Center, UPMC Stroke Institute Pittsburg PA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In patients undergoing mechanical thrombectomy for acute ischemic stroke, a few studies have compared transradial access (TRA) to transfemoral access (TFA) with inconsistent results. We conducted this systematic review and meta-analysis to provide comprehensive evidence regarding the comparison of procedural and clinical outcomes of TRA versus TFA in patients with acute ischemic stroke undergoing mechanical thrombectomy. Methods: We performed a comprehensive literature search of 4 electronic databases from inception until May 1, 2022. After title and full text screening, relevant data were extracted and then analyzed. For outcomes that constituted continuous data, the mean difference between the 2 groups and its SD were pooled. For outcomes that constituted dichotomous data, the frequency of events and the total number of patients in each group were pooled as odds ratio (OR) between the 2 groups. Results: Nine observational studies were included in this meta-analysis. The population of the studies was homogenous comprising a total of 2161 patients undergoing mechanical thrombectomy, including 446 patients via TRA and 1715 patients via TFA. There were no significant differences across the 2 groups in terms of successful recanalization (OR, 0.83 [95% CI, 0.55-1.25]; Conclusion: In patients undergoing mechanical thrombectomy for acute ischemic stroke, the collective evidence suggests that TRA seems to result in lower rates of access site complications than TFA without significant compromise in other clinical or procedural metrics. Randomized or prospective studies are warranted to confirm these results.

Indexed as

strokethrombectomytransfemoraltransradial

Identifiers

PMID41583675
PMCPMC12778673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.