Evidence map›Paper›PMID 41583619›Full record

ArticleArchives of medical sciences. Atherosclerotic diseases2025

The history of cardiopulmonary bypass and the evolution of

Vasileios Leivaditis, Georgios Mavroudes, Hermann Braun Lambur, Nikolaos Baikoussis, Elias Liolis, Konstantinos Tasios, Levan Tchabashvili, George Theofanis, Andreas Antzoulas, Dimitrios Litsas and 5 more

Abstract read
In one paragraph

Article in Archives of medical sciences. Atherosclerotic diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vasileios LeivaditisDepartment of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, Kaiserslautern, Germany.
Georgios MavroudesSchool of Social Anthropology, University of Sussex, Falmer, Brighton, UK.
Hermann Braun LamburDepartment of Internal Medicine/Pneumonology, Westpfalz Klinikum, Kaiserslautern, Germany.
Nikolaos BaikoussisDepartment of Cardiac Surgery, Ippokrateio General Hospital of Athens, Greece.
Elias LiolisDepartment of Oncology, University General Hospital of Patras, Greece.
Konstantinos TasiosDepartment of General Surgery, University General Hospital of Patras, Greece.
Levan TchabashviliDepartment of General Surgery, University General Hospital of Patras, Greece.
George TheofanisDepartment of General Surgery, University General Hospital of Patras, Greece.
Andreas AntzoulasDepartment of General Surgery, University General Hospital of Patras, Greece.
Dimitrios LitsasDepartment of General Surgery, General Hospital of Lamia, Greece.
Panagiotis Dimitrios PapadopoulosDepartment of Surgery, Spital Herisau, Appenzell Ausserrhoden, Switzerland.
Konstantinos NikolakopoulosDepartment of Vascular Surgery, University General Hospital of Patras, Greece.
Manfred DahmDepartment of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, Kaiserslautern, Germany.
Spyros PapadoulasDepartment of Vascular Surgery, University General Hospital of Patras, Greece.
Francesk MulitaDepartment of General Surgery, University General Hospital of Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs. This article begins with ancient concepts of cardiopulmonary function, then traces the evolution of CPB through important physiological and anatomical discoveries, culminating in the development of the modern heart-lung machine. In addition to examining the contributions of significant figures such as Galen, Ibn al-Nafis, William Harvey, and John Gibbon, we also explore the ethical and technical challenges encountered in the early days of open-heart surgery. The historical trajectory of

Indexed as

cardiopulmonary bypassextracorporeal circulationheart-lung machinemedical historyperfusion technologysurgical innovation

Identifiers

PMID41583619
PMCPMC12828647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.