ArticleiScience2026
Chronic stress antagonizes formation of stress granules.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- RNA G-quadruplex-protein interactions: from nuclear RNA processing to cytoplasmic stress response and neurodegeneration.RNA biology · 2026Review
- RNA-binding proteins: a comprehensive review of multifaceted regulatory mechanisms in neuroinflammation and implications in the pathogenesis of neurological disorders.Journal of neuroinflammation · 2026Review
- Two-Nanosensor Electrochemical Profiling of Catecholamine Vesicle Interactions With Acute and Chronic Stress Granules in Living Cells.Angewandte Chemie (International ed. in English) · 2026Article
- Chronic stress disrupts the network among stress granules, P-bodies, and motor proteins.bioRxiv : the preprint server for biology · 2026Article
- RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration.Journal of neurochemistry · 2025Review
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Authors and funding
6 authors.
Funding
Abstract
Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and polysome disassembly. Despite the broad interest in SG assembly and disassembly in response to acute stress, SG dynamics under chronic stress has not been extensively investigated. We show that cells pre-conditioned with low-dose chronic (24 h exposure) stresses of various natures fail to assemble SGs in response to acute stress. While protein synthesis is drastically decreased by acute stress in pre-conditioned cells, polysome profiling analysis reveals the partial preservation of polysomes. Mechanistically, chronic stress slows down the rate of mRNA translation at the elongation phase, and triggers phosphorylation of translation elongation factor eEF2. These events further promote ribosome stalling, which is distinct from ribosome collisions known to trigger ribosome-associated quality-control pathways. In summary, chronic stress triggers ribosome stalling, which prevents efficient polysome disassembly and SG formation by subsequent acute stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.