Evidence map›Paper›PMID 41583562›Full record

ArticleiScience2026

Comparative transcriptomic analysis of embryonic stem cells across mammalian species.

Yifei Fang, Yue Su, Richard Meisel, James R Walters, Tony Gamble, Eric C Randolph, Xingtan Yu, Meihong Shi, Guangsheng Li, Jingzhi Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yifei FangDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.
Yue SuShaanxi Centre of Stem Cells Engineering & Technology, Key Laboratory of Livestock Biology, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Richard MeiselDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
James R WaltersDepartment of Ecology and Evolutionary Biology, The University of Kansas, Lawrence, KS, USA.
Tony GambleDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA.
Eric C RandolphDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Xingtan YuDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.
Meihong ShiDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.
Guangsheng LiDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.
Jingzhi ZhangDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.
IISAGE Consortium
Xiuchun Cindy TianDepartment of Animal Science, Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Young TangShaanxi Centre of Stem Cells Engineering & Technology, Key Laboratory of Livestock Biology, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Jingyue Ellie DuanDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pluripotency, the ability of cells to self-renew and differentiate into all body lineages, is vital for mammalian early development. This study presented a comprehensive comparative transcriptomic analysis of embryonic stem cells across multiple mammalian species, defining their progression through expanded/extended, naive, formative, and primed pluripotency states. Our findings revealed both conserved and species-specific mechanisms underlying pluripotency regulation. We also emphasized the limitations of existing state-specific markers and their limited cross-species applicability, while identifying

Indexed as

Evolutionary developmental biologyMolecular networkStem cells researchTranscriptomics

Identifiers

PMID41583562
PMCPMC12828385

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.