Evidence map›Paper›PMID 41583528›Full record

ArticleInternational journal of medical sciences2026

Deletion of the Mouse Homolog of Human FHR1 (muFHR1) Alleviates Atherosclerosis in ApoE-/- mice.

Luce Perie, Sarah M Herr, Tomas Ghebreslassie, Sonia Wulf, Ina Löschmann, Andjela Sekulic, Abdulhadi Suwandi, Anna-Karina B Maier, Luca Rowlin, Berit Jungnickel and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luce PerieDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, 07745, Germany.
Sarah M HerrInstitute of Cell Biochemistry, Hannover Medical School, Hannover, 30625 Germany.
Tomas GhebreslassieDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, 07745, Germany.
Sonia WulfInstitute of Pathology, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany.
Ina LöschmannDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, 07745, Germany.
Andjela SekulicExperimental Ophthalmology, Charité - University Medicine Berlin, Corporate Member of Freie Universität, Berlin Institute of Health, Humboldt-University, 10117, Berlin, Germany.
Abdulhadi SuwandiInstitute of Cell Biochemistry, Hannover Medical School, Hannover, 30625 Germany.
Anna-Karina B MaierDepartment of Ophthalmology, Charité - University Medicine Berlin, Corporate Member of Freie Universität, Berlin Institute of Health, Humboldt-University, 10117, Berlin, Germany.
Luca RowlinDepartment of Ophthalmology, Charité - University Medicine Berlin, Corporate Member of Freie Universität, Berlin Institute of Health, Humboldt-University, 10117, Berlin, Germany.
Berit JungnickelDepartment of Cell Biology, Institute of Biochemistry and Biophysics, Friedrich-Schiller University, 07745 Jena, Germany.
Sascha SchäubleDepartment of Microbiome Dynamics, Leibniz Institute of Natural Product Research and Infection Biology, 07745 Jena, Germany.
Gianni PanagiotouFaculty of Biosciences, Friedrich Schiller University, 07743 Jena, Germany.
Olaf StraußExperimental Ophthalmology, Charité - University Medicine Berlin, Corporate Member of Freie Universität, Berlin Institute of Health, Humboldt-University, 10117, Berlin, Germany.
Thorsten WiechInstitute of Pathology, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany.
Peter F ZipfelDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, 07745, Germany.
Svante L H ZipfelClinic for Heart and Visceral Surgery, University Heart and Vascular Center Hamburg, Medical University Hamburg-Eppendorf, 20246 Hamburg, Germany.
Christine SkerkaDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, 07745, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is the leading cause of heart attack and stroke worldwide. The key characteristic of atherosclerosis is accumulation of LDL cholesterol in artery walls, the subsequent infiltration by monocytes/macrophages, and the development of inflammation. Recently, we reported that plasma protein complement factor H-related 1 (FHR1) binds to the necrotic surfaces of cardiovascular plaques and induces inflammation. Moreover, the concentration of FHR1 is higher, whereas

Indexed as

AtherosclerosisBlood ProteinsComplement C3b Inactivator ProteinsAnimalsApolipoproteins ECholesterol, LDLDisease Models, AnimalFoam CellsGene DeletionHumansInflammationLipoproteins, LDLLiverMacrophagesMaleMiceApolipoproteins EBlood ProteinsCFHR1 protein, humanCholesterol, LDLComplement C3b Inactivator ProteinsLipoproteins, LDLoxidized low density lipoproteinatherosclerosischolesterolcomplement factor H-related protein 1inflammationoxLDL

Identifiers

PMID41583528
PMCPMC12825125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.