Evidence map›Paper›PMID 41583519›Full record

ReviewInternational journal of medical sciences2026

Bioengineering modification and application of bacterial outer membrane vesicles.

Yedu Wen, Yidi Si, Xinni Jia, Zhongyu Han, Zihe Zhou, Zhenchao Wu, JiaJia Zheng

Abstract readReview
In one paragraph

Review in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. [Preparation of HLYVSPW peptide-displaying outer membrane vesicles and validation of their in vitro targeting effects on triple-negative breast cancer cells].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yedu WenDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
Yidi SiDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
Xinni JiaDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
Zhongyu HanDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
Zihe ZhouDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
Zhenchao WuDepartment of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.
JiaJia ZhengDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Outer Membrane Vesicles (OMVs) are spherical nanovesicles naturally secreted by Gram-negative bacteria, playing key roles in nutrient uptake, toxin delivery, and the transmission of drug resistance. Recent studies have increasingly focused on the clinical potential of OMVs. Due to their remarkable biocompatibility and immunogenic properties, OMVs offer wide-ranging applications in vaccine development and antigen/drug delivery, showing great promise in the treatment of tumors, autoimmune diseases, and infections. However, challenges remain in standardizing the production and modification of OMVs, limiting their broader application. This review consolidates research on OMV modification and application, aiming to provide valuable insights to advance the development of OMV-based therapeutic strategies and clinical implementations.

Indexed as

Bacterial Outer MembraneBacterial Outer Membrane ProteinsBioengineeringGram-Negative BacteriaAnimalsDrug Delivery SystemsHumansNeoplasmsVaccine DevelopmentBacterial Outer Membrane Proteinsbioengineering modificationsclinical applicationsOMVs

Identifiers

PMID41583519
PMCPMC12825007

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.