Evidence map›Paper›PMID 41583474›Full record

ArticleFrontiers in immunology2025

Anuradha Rajamanickam, Bindu Dasan, Arul Nancy Pandiarajan, Saravanan Munisankar, Sivakumar Shanmugam, Subash Babu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anuradha RajamanickamNational Institute of Health-National Institute of Allergy and Infectious Diseases-International Center for Excellence in Research, Chennai, India.
Bindu DasanNational Institute of Health-National Institute of Allergy and Infectious Diseases-International Center for Excellence in Research, Chennai, India.
Arul Nancy PandiarajanNational Institute of Health-National Institute of Allergy and Infectious Diseases-International Center for Excellence in Research, Chennai, India.
Saravanan MunisankarNational Institute of Health-National Institute of Allergy and Infectious Diseases-International Center for Excellence in Research, Chennai, India.
Sivakumar ShanmugamDepartment of Bacteriology, Indian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, India.
Subash BabuNational Institute of Health-National Institute of Allergy and Infectious Diseases-International Center for Excellence in Research, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Helminth co-infection are common in tuberculosis (TB) endemic regions and alter host immunity. However, their impact on immune responses in TB infection (TBI) remains incompletely defined. Methods: We analyzed QuantiFERON (QFT) supernatants and peripheral blood mononuclear cells (PBMCs) from TBI+Hel+ ( Results: We measured Type 1 (IFN-γ, TNF-α, IL-2), Type 17 (IL-17, IL-22), and proinflammatory cytokines (IL-1α, IL-1β) in QuantiFERON (QFT) supernatants from TBI individuals with (TBI+Hel+) and without (TBI+Hel-) infection. TBI+Hel+ individuals exhibited significantly reduced mycobacterial growth inhibition compared with TBI+Hel- individuals, reflected by higher normalized mycobacterial growth (Δ log10 CFU). Cytokine analysis showed suppression of Th1/Th17 (IFN-γ, IL-2, TNF-α, IL-17, GM-CSF) and proinflammatory cytokines (IL-1α, IL-1β, IL-6, IL-12p70, IL-18) in TBI+Hel+ individuals, alongside increased Th2/regulatory cytokines (IL-4, IL-5, IL-10, IL-13). Conclusions:

Indexed as

CoinfectionMycobacterium tuberculosisStrongyloides stercoralisStrongyloidiasisTuberculosisAdultAnimalsCytokinesFemaleHumansLeukocytes, MononuclearMaleMiddle AgedTh1 CellsCytokinescytokinesimmune modulationMGIAStrongyloides stercoralis infectionTh1/Th2 balancetuberculosis infection

Identifiers

PMID41583474
PMCPMC12827546

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.