ArticleFrontiers in immunology2025
Different Fc scaffolds enhance the breadth of
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rotaviruses are the primary cause of severe dehydrating diarrhea in infants and young children globally. Currently, several oral rotavirus vaccines are available; however, they have shown reduced effectiveness and quicker waning of protection in low- and middle-income countries (LMICs) compared to high-income countries (HICs). Both neutralizing and non-neutralizing antibodies against the middle (VP6) and outer layer capsid proteins (VP4 and VP7) are detected after infection, with higher titers being linked to disease protection. Historically, human derived rotavirus-specific monoclonal antibodies (mAbs) have been produced in an IgG1 scaffold, irrespective of whether their native scaffold was IgG or IgA. To explore the impact of antibody scaffolds on their functional activity we expressed mAbs targeting epitopes on VP8* or VP7 viral proteins in IgG1, IgG2, IgG3, IgG4, IgA1, and IgA2 scaffolds (the latter either in a monomeric or in a dimeric IgA form). The mAbs were characterized for their binding affinity to the viral target and their functionality was evaluated in an
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