Evidence map›Paper›PMID 41583458›Full record

ArticleFrontiers in immunology2025

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function.

Emily C Reed, Tatlock H Lauten, Tamara Natour, Lauren J Pitts, Caroline N Jojo, Brooke L Griffin, Sreeram Pasupuleti, Adam J Case

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Prognostic value of the CHAM score in non-small cell lung cancer patients treated with nivolumab.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Emily C ReedDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
Tatlock H LautenDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
Tamara NatourDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
Lauren J PittsDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
Caroline N JojoDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
Brooke L GriffinDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
Sreeram PasupuletiDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
Adam J CaseDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.

Funding

Neuroimmune dynamics involved in the pathogenesis of hypertension after psychological traumaR01HL158521 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CASE, ADAM J · 2021 to 2025
$2.7M
Diverse Predoctoral Training in GeneticsT32GM135115 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ADELMAN, ZACH N. · 2020 to 2024
$901k
Deciphering the autonomic regulation of inflammation and hypertension sensitization after psychological traumaF31HL176172 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LAUTEN, TATLOCK H · 2024 to 2024
$38k
NHLBI NIH HHS F31 HL176172NHLBI NIH HHS R01 HL158521NIGMS NIH HHS T32 GM135115
6 · The paper itself

Abstract

We have recently discovered hemoglobin alpha a1 (Hbα-a1 mRNA and Hbα protein) in T-lymphocytes and previously reported that its expression was sensitive to mitochondrial redox perturbations. However, outside of its occurrence and basic characterization, the functional role of Hbα in T-lymphocytes remained unknown. Herein, we identify Hbα in both CD4

Indexed as

alpha-GlobinsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalLymphocyte ActivationMitochondriaT-LymphocytesAnimalsCytokinesFemaleMiceMice, Inbred C57BLMice, Knockoutalpha-GlobinsCytokinesEAEhemoglobinopathyimmuneInflammationredox

Identifiers

PMID41583458
PMCPMC12823933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.