Impact of preformed donor-specific anti-human leukocyte antigen antibodies on the clinical outcomes in pediatric liver transplantation patients: a retrospective cohort study.

Zhong-Yu Kang, Chun Liu, Wei Liu, Xueya Han, Daihong Li

Abstract read

In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhong-Yu KangDepartment of Blood Transfusion, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.

Chun LiuDepartment of Blood Transfusion, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.

Wei LiuDepartment of Blood Transfusion, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.

Xueya HanDepartment of Blood Transfusion, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.

Daihong LiDepartment of Blood Transfusion, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The impact of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) in pediatric liver transplantation (LT) have been widely studied. The effect of preformed DSAs in pediatric LT is still controversial. This study aimed to evaluate the prevalence of preformed DSAs and their impact on clinical outcomes in pediatric LT recipients. Methods: This single-center retrospective cohort study included 243 pediatric patients who underwent LT between January 2019 and December 2022. The patients were divided into two groups according to the result of the pretransplant HLA antibody determined by Luminex™ Single Antigen Bead assay. The clinical outcomes, rejection, graft loss, patient survival, and the evolution of preformed DSAs were analyzed. Results: Thirty-one (12.7%) of the 243 patients had preformed DSAs, with most identified as class II DSAs. Among the patients with preformed DSAs, four had persistent preformed DSA, two had Conclusion: This study showed that preformed DSAs were not associated with histologic or clinical outcomes in pediatric LT patients. Further studies with a larger sample size to obtain more reliable results are required to verify the risk associated with preformed DSAs in pediatric LT patients.

Indexed as

Graft RejectionHLA AntigensIsoantibodiesLiver TransplantationAdolescentChildChild, PreschoolFemaleGraft SurvivalHumansInfantMaleRetrospective StudiesTissue DonorsTreatment OutcomeHLA AntigensIsoantibodiesantibody-mediated rejectionDSAgraft losspediatric liver transplantationsurvivalT cell-mediated rejection

Identifiers

PMID41583456

DOI10.3389/fimmu.2025.1703788

PMCPMC12827091

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.