ArticleCureus2025
A Rare Continuum From Oral Submucous Fibrosis to Spindle Cell Squamous Carcinoma: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Targeting oral squamous cell carcinoma with venom peptides: mechanisms, selectivity and translational potential.The protein journal · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spindle cell squamous carcinoma (SpCC) is a rare, aggressive sarcomatoid variant of squamous cell carcinoma (SCC) characterized by biphasic epithelial-mesenchymal morphology. Oral submucous fibrosis (OSMF), a potentially malignant disorder prevalent in South-Asia typically transforms into conventional SCC, while direct transformation into SpCC is exceedingly uncommon. We report the case of a 49-year-old male previously treated for OSMF who, four years later, developed a fissural defect in the right buccal vestibule without an exophytic mass. He returned one week later with numbness of the right lower lip and chin. An incisional biopsy demonstrated well-differentiated SCC, while definitive resection revealed predominant spindle-cell morphology consistent with SpCC (pT4aN2a). The histologic continuity between epithelial and spindle components suggests early epithelial dedifferentiation within the OSMF microenvironment, likely mediated by TGF-β-driven epithelial-mesenchymal transition. This case underscores the malignant potential of OSMF and highlights the importance of recognizing such atypical malignant transformations, which are vital for timely diagnosis and intervention.
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Registered trials
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