ArticleCureus2025
Conservative Management of Primary Thyroid Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma: A Case Report and Review of Multidisciplinary Approach.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Primary thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is a rare condition. It often progresses slowly and has subtle symptoms. This condition is usually linked with chronic thyroiditis. We present the case of a 70-year-old man who experienced progressive dysphagia and neck swelling for six months. He was found to have a large multinodular goitre and background hypothyroidism. Despite a fine-needle aspiration that did not provide a diagnosis, doctors decided to perform surgery because of his compressive symptoms. Histopathology showed extranodal marginal zone MALT lymphoma alongside chronic lymphocytic thyroiditis. Postoperative PET/CT and bone marrow tests revealed no signs of systemic involvement. After a review by a multidisciplinary tumor board, the patient was treated conservatively without additional therapy. He showed no signs of recurrence during the one-year follow-up. This case highlights the diagnostic challenges and underscores the importance of considering MALT lymphoma when evaluating goitre. It also demonstrates that individualized, conservative management guided by a multidisciplinary team can lead to excellent outcomes in localized disease.
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