Evidence map›Paper›PMID 41583128›Full record

ArticleCurrent developments in nutrition2026

Sex Differences in Measures of Energy Expenditure and Body Composition in Young, Middle-Aged, and Older Adults.

Hannah E Cabre, Kara L Marlatt, Rodrigo Fernández-Verdejo, Robbie Beyl, Leanne M Redman, Philip N Ainslie, Heliodoro Alemán-Mateo, Lene F Andersen, Liam J Anderson, Lenore Arab and 64 more

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Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

74 authors.

Hannah E CabrePennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Kara L MarlattAdvisory Board, Washington, DC, United States.
Rodrigo Fernández-VerdejoPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Robbie BeylPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Leanne M RedmanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Philip N AinslieResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Heliodoro Alemán-MateoBody Composition and Functionality Laboratory, Center for Food and Development Research, A.C., Hermosillo, Sonora, México.
Lene F AndersenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway.
Liam J AndersonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Lenore ArabDavid Geffen School of Medicine, University of California, Los Angeles, United States.
Kweku Bedu-AddoDepartment of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Alberto G BonomiPhillips Research, Eindhoven, The Netherlands.
Carlijn Vc BoutenDepartment of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
Pascal BovetUniversity Center for Primary Care and Public Health (Unisanté), Lausanne, Switzerland.
Soren BrageMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Maciej S BuchowskiDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, Nashville, TN, United States.
Nancy F ButteDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, United States.
Stefan G CampsClinical Nutrition Research Center, Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research (A∗STAR) and National University Health System, Singapore.
Regina CasperPsychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States.
Graeme L CloseResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Lisa H ColbertKinesiology, University of Wisconsin, Madison, WI, United States.
Jamie A CooperDepartment of Nutritional Sciences, University of Wisconsin, Madison, WI, United States.
Richard CooperDepartment of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, United States.
Sai Krupa DasJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Sanjoy DebCentre for Nutraceuticals, School of Life Sciences, University of Westminster, London, United Kingdom.
Terrence ForresterSolutions for Developing Countries, University of the West Indies, Kingston, Jamaica.
Melanie GillinghamDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, United States.
Annelies H GorisMaastricht University, Maastricht, The Netherlands.
Michael GurvenDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, CA, United States.
Catherine HamblyInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Sumei HuState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Annemiek M JoosenMaastricht University, Maastricht, The Netherlands.
Peter KatzmarzykPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Kitty P KempenMaastricht University, Maastricht, The Netherlands.
Misaka KimuraInstitute for Active Health, Kyoto University of Advanced Science, Kyoto, Japan.
William E KrausDepartment of Medicine, Duke University, Durham, NC, United States.
Wantanee KriengsinyosInstitute of Nutrition, Mahidol University, Bangkok, Thailand.
Robert F KushnerFeinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Nader LessanImperial College London Diabetes Centre, Imperial College London, London, United Kingdom.
Marie LöfDepartment of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Corby K MartinPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Eric MatsikoDepartment of Human Nutrition and Dietetics, University of Rwanda, Kigali, Rwanda.
Anine C MedinDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway.
James C MorehenResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
James P MortonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center and School of Public Health, University of Washington, Seattle, WA, United States.
Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center and School of Public Health, University of Washington, Seattle, WA, United States.
Susan B RacetteArizona State University Phoenix, Phoenix, AZ, United States.
David A RaichlenBiological Sciences and Anthropology, University of Southern California, CA, United States.
Rebecca M ReynoldsCentre for Cardiovascular Sciences, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Susan B RobertsGeisel School of Medicine, Dartmouth College, Hanover, NH, United States.
Luís B SardinhaExercise and Health Laboratory, CIPER, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
Albertine J SchuitWageningen University & Research Centre Health and Society, University of Wageningen, Wageningen, The Netherlands.
Analiza M SilvaExercise and Health Laboratory, CIPER, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
Samuel S UrlacherDepartment of Anthropology, Baylor University, Waco, TX, United States.
Mauro Eduardo ValenciaBody Composition and Functionality Laboratory, Center for Food and Development Research, A.C., Hermosillo, Sonora, México.
Ludo M Van EttenMaastricht University, Maastricht, The Netherlands.
Jeanine A VerbuntMaastricht University, Maastricht, The Netherlands.
George WilsonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Brian M WoodDepartment of Anthropology, University of California Los Angeles, Los Angeles, CA, United States.
Tsukasa YoshidaNational Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
Xueying ZhangInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Alexia J Murphy-AlfordNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.
Cornelia U LoechlNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.
Amy H LukeDivision of Epidemiology, Department of Public Health Sciences, Loyola University School of Medicine, Maywood, IL, United States.
Herman PontzerEvolutionary Anthropology, Duke University, Durham, NC, United States.
Jennifer RoodPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Hiroyuki SagayamaFaculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
Dale A SchoellerBiotech Center and Nutritional Sciences University of Wisconsin, Madison, WI, United States.
Klaas R WesterterpNutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
William W WongDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, United States.
Yosuke YamadaInstitute for Active Health, Kyoto University of Advanced Science, Kyoto, Japan.
John R SpeakmanInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Eric RavussinPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.

Funding

Nutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3M
NCI NIH HHS R01 CA119171
6 · The paper itself

Abstract

Background: Total daily energy expenditure (TDEE) is vital for energy balance and cardiometabolic health, yet its trajectory across the lifespan, particularly in females, remains poorly understood. Objectives: We sought to examine the effects of aging and sex on body composition and TDEE. Methods: In a cross-sectional analysis of data from research centers across 9 European Countries and the United States from the International Atomic Energy Agency database, TDEE and body composition measures of 2326 participants (1560W/766M; 50.7 ± 12 .6 y) were stratified across age groups: young (30-39 y; YOUNG), middle-aged (40-54 y; MID), and old (55-70 y; OLD). Doubly labeled water was used to estimate TDEE and fat-free mass (FFM). Fat mass (FM) was calculated as the difference between body mass and FFM, and %fat was ratio between FM and body mass as a percentage. Linear models were used for analysis. Results: Females demonstrated greater FM and lower FFM with each age group, compared with males ( Conclusions: These results suggest that age influences changes in body composition and energy expenditure similarly between males and females. The most significant change in TDEE occurs as individuals transition from middle age to older adulthood. Females generally have a higher percentage of %fat and FM, along with lower FFM, compared with males across all age groups. These findings are important for understanding how aging affects metabolism and body composition, which could inform sex-specific health strategies and interventions.

Indexed as

agingbody compositionenergy balancemenopauseobesitysex differencestotal daily energy expenditure

Identifiers

PMID41583128
PMCPMC12830153

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.