ArticleStroke (Hoboken, N.J.)2023
Time to Reperfusion Is Not Associated With Functional Outcomes in First-Pass Reperfusion: Analysis of the STRATIS Registry.
Article in Stroke (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Enhanced Complete Clot Ingestion with the ALGO Smart Pump: Preclinical Evidence Supporting Aspiration Efficiency in Mechanical Thrombectomy.Clinical neuroradiology · 2026Article
- Direct endovascular treatment may be more appropriate for patients with good collateral circulation: a retrospective case-control study.Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Time is considered a fundamental driver of treatment success in ischemic stroke reperfusion therapy. First-pass reperfusion (FPR) is associated with improved outcomes. We explored the association between time to reperfusion, FPR, and functional outcomes in an analysis of the STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) registry data. Methods: Registry patients with anterior circulation stroke, treated with endovascular thrombectomy and achieving complete or near-complete expanded Thrombolysis in Cerebral Infarction scale (eTICI) 2c/3 reperfusion per core laboratory assessment were included. FPR was considered eTICI 2c/3 reperfusion in a single device pass. Patients undergoing multipass reperfusion required ≥2 device passes to achieve the same, total, or near-total reperfusion (eTICI 2c/3). Logistic regression was used to model functional independence, defined as a modified Rankin scale score of 0 to 2 at 3 months, as a function of time to reperfusion, comparing FPR and multipass reperfusion patient populations. Results: Of the 984 patients in the STRATIS registry, 563 patients achieved eTICI 2c/3 reperfusion of anterior circulation large-vessel occlusions and were eligible for inclusion in the analysis. In patients undergoing multipass reperfusion (n=186), increased time to treatment was associated with a decreased likelihood of a good clinical outcome. Odds ratio for every 60-minute delay to treatment: 0.71 (95% CI, 0.55-0.90; Conclusion: First-pass reperfusion may compensate for the effects of delays to reperfusion on functional outcomes in ischemic stroke.
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