ArticleFrontiers in aging neuroscience2025
Separating cognitive and motor contributions to iADL difficulties in Parkinson's disease.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mild Cognitive Impairment (MCI) and dementia are distinguished by whether cognitive deficits interfere with independent performance of instrumental activities of daily living (iADLs). In Parkinson's disease (PD) this distinction is challenging due to the combined impact of motor and cognitive symptoms on autonomy. To address this, we examine two methods aimed at isolating these contributions using the Functional Activities Questionnaire (FAQ): (1) a modified scoring method that classifies items as motor or cognitive to compute a ratio of the two contributors (FAQ Methods: We conducted a retrospective chart review of PD patients ( Results: Patients and care-partners reported that iADLs were more limited by motor symptoms, even for items categorized as "cognitive." Regression models did not achieve the same item classification as prior research using the modified scoring method. The RCB, but not the FAQ Conclusion: Patient's and care-partner's appraisal of the source of iADL difficulties was inconsistent with previous categorization of FAQ items in patients with more advanced PD. Our novel RCB offers a sensitive means of detecting mild functional changes related to cognition even in the presence of highly disabling motor symptoms, and may aid in establishing cognitive diagnoses in PD and other neurodegenerative disorders.
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