ArticleFrontiers in aging neuroscience2025
Mechanistic insights into the anti-neuroinflammatory effects of cassia
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder that is closely associated with neuroinflammation, yet effective anti-inflammatory therapies remain limited. This study aimed to elucidate the potential mechanisms of Methods: Network pharmacology was employed to identify bioactive compounds, candidate targets, and enriched pathways, followed by protein-protein interaction (PPI) analysis and molecular docking. Rhein, a representative compound, was further validated in LPS-induced BV2 microglial cells using CCK-8, NO detection, ELISA, and Western blot assays. Results: A total of 114 candidate targets were identified, with enrichment highlighting NF-κB, MAPK, and NLRP3 inflammasome pathways. Molecular docking revealed strong binding affinity between rhein and NF-κB p65. Conclusion:
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