ArticleStroke (Hoboken, N.J.)2022
Risk Factors of Futile Recanalization Following Endovascular Treatment in Patients With Large-Vessel Occlusion: Systematic Review and Meta-Analysis.
Article in Stroke (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Annals of neurology · 2025Pooled it
- Transcranial doppler (TCD) in predicting outcomes following successful mechanical thrombectomy of large vessel occlusions in anterior circulation: a systematic review and meta-analysis.Journal of neurointerventional surgery · 2025Pooled it
- Progressive microvascular failure in acute ischemic stroke: A systematic review, meta-analysis, and time-course analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular reperfusion: Systematic review of the clinical literature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Futile recanalization after mechanical thrombectomy in patients with acute ischemic stroke and large ischemic core.Journal of cerebrovascular and endovascular neurosurgery · 2026Article
- The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - anInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Impact of Middle Cerebral Artery Branching Patterns on Mechanical Thrombectomy Outcomes for M1 Occlusion.Neurologia medico-chirurgica · 2026Article
- Peri-procedural and early body temperature trajectories after endovascular thrombectomy and clinical outcomes in intensive care unit patients with acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
- FRET score: predictors of futile recanalisation following endovascular thrombectomy-a multicentre cohort study from the EVATRISP collaboration.European stroke journal · 2026Observational
- Age-Specific Differences in Inflammatory Biomarkers and Their Impact on Futile Recanalization After Mechanical Thrombectomy: An Inverse Probability Weighting Analysis.European journal of neurology · 2025Observational
- Endovascular Thrombectomy versus Medical Management for Acute Basilar Artery Occlusion Stroke in the Elderly.AJNR. American journal of neuroradiology · 2025Article
- The immunology of stroke and dementia.Immunity · 2025Review
- Predictive role of a combined model for futile recanalization in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2025Article
- Predictors of futile recanalization in ischemic stroke patients with low baseline NIHSS.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Futile recanalization after endovascular treatment in acute ischemic stroke with large ischemic core.BMC neurology · 2024Article
- A Deep Learning Approach to Predict Recanalization First-Pass Effect following Mechanical Thrombectomy in Patients with Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2024Article
- Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study.Journal of neurology · 2024Observational
- Arterial Stiffness Predicts the Outcome of Endovascular Treatment in Patients with Acute Ischemic Stroke.Journal of clinical medicine · 2024Article
- Introducing the Futile Recanalization Prediction Score (FRPS): A Novel Approach to Predict and Mitigate Ineffective Recanalization after Endovascular Treatment of Acute Ischemic Stroke.Neurology international · 2024Article
- Predictions for functional outcome and mortality in acute ischaemic stroke following successful endovascular thrombectomy.BMJ neurology open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although successful recanalization (modified Thrombolysis in Cerebral Infarction score 2b-3) can be achieved in >80% of patients experiencing stroke attributable to large-vessel occlusion, up to 50% of patients may develop poor clinical outcomes (modified Rankin scale score at 90 days of 3-6), termed as futile recanalization (FR). The meta-analysis aims to determine various risk factors associated with FR. Methods: In February 2021, a comprehensive literature search on risk factors associated with FR was performed with keywords, including "stroke," "thrombectomy," "treatment outcome," and "risk factors." Their correlations with FR were evaluated using the random effect size meta-analysis model. Results: Twenty studies with 3037 patients were included with an FR rate of 51.0%. Our meta-analyses showed that age (mean difference [MD], 5.6; 95% CI, 4.7-6.6), National Institutes of Health Stroke Scale score (MD, 4.2; 95% CI, 3.2-5.1), Alberta Stroke Program Early Computed Tomography (CT) Score (MD, -0.5; 95% CI, 0.8-0.3), hypertension (odds ratio [OR], 1.5; 95% CI, 1.3-1.9), systolic blood pressure (MD, 6.9; 95% CI, 3.6-8.7), atrial fibrillation (OR, 1.5; 95% CI, 1.2-1.8), IV tPA (tissue-type plasminogen activator) (OR, 0.7; 95% CI, 0.5-0.8), puncture to recanalization time (MD, 9.6; 95% CI, 5.3-13.8), and time of onset to recanalization (MD, 32.1; 95% CI, 6.5-47.7) were significantly associated with FR ( Conclusions: Age, admission National Institutes of Health Stroke Scale score, Alberta Stroke Program Early CT Score, comorbidities, including hypertension, systolic blood pressure, atrial fibrillation, and use of IV tPA, as well as time frames, including onset to recanalization and onset to arrival, were significant influencing factors for FR after mechanical thrombectomy. Future research on the mechanism underlying FR is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.