Evidence map›Paper›PMID 41582951›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Small adipose-derived mesenchymal stromal cells exhibit longer telomeres and enhanced regenerative potential.

Uldis Berzins, Janis Baronins, Hermanis Sorokins, Saurav Goel, Andrei Shishkin, Rosita Zvirgzdina, Aija Rautmane, Danail Minchev

Abstract read
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In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Uldis BerzinsBiochip Scientific Laboratory, Faculty of Civil and Mechanical Engineering, Mechanical and Biomedical Engineering Institute, Riga Technical University, Riga, Latvia.
Janis BaroninsFaculty of Natural Sciences and Technology, Institute of Physics and Materials Science, Riga Technical University, Riga, Latvia.
Hermanis SorokinsBiochip Scientific Laboratory, Faculty of Civil and Mechanical Engineering, Mechanical and Biomedical Engineering Institute, Riga Technical University, Riga, Latvia.
Saurav GoelSchool of Engineering and Design, London South Bank University, London, United Kingdom.
Andrei ShishkinFaculty of Natural Sciences and Technology, Institute of Physics and Materials Science, Riga Technical University, Riga, Latvia.
Rosita Zvirgzdina"Turiba University" Ltd., Riga, Latvia.
Aija RautmaneFaculty of Natural Sciences and Technology, Institute of Physics and Materials Science, Riga Technical University, Riga, Latvia.
Danail MinchevDepartment of Human Anatomy and Physiology, Faculty of Biology, Paisii Hilendarski University of Plovdiv, Plovdiv, Bulgaria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Younger, replicative cells with longer telomeres can enhance regenerative therapies, however, there is a lack of a standard method to assess telomere length in live cells. The present study investigated whether the relative size of human adipose tissue-derived mesenchymal stromal cells (AD-MSCs) can influence their telomere length. During early culture, a smaller-sized AD-MSC subpopulation was identified based on characteristic colony emergence. Telomere lengths in total and smaller-sized cell populations were measured. Polymerase chain reaction revealed expression of Nanog and OCT3/4 in small-sized AD-MSCs. Their safety was evaluated in immunodeficient BALB/c nude mice. Smaller AD-MSCs revealed distinct growth properties, with the cell monolayer rolling up into a large aggregate. These cells had longer telomeres (18,121.43 base pairs [bp]) than the total population (15,870.44 bp) and formed teratoma-like structures with skin-like morphology (including hair). In conclusion, AD-MSC size reliably isolates cells with longer telomeres and potential.

Indexed as

AD–MSCsBALB/c nude micecell rollingcell sizehypoxiamesenchymal stromal cellstelomere length

Identifiers

PMID41582951
PMCPMC12823908

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.