ArticleJournal of periodontology2026
Mineral-targeted alkaline phosphatase improves bone graft-mediated alveolar bone defect healing in mice.
Article in Journal of periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlveolar bone loss challenges tooth retention and implant placement. Freeze-dried bone allograft (FDBA) is widely used for alveolar ridge preservation but has limitations in resorption rate and healing time. In this proof-of-concept study, we tested whether pro-mineralization enzyme, tissue-nonspecific alkaline phosphatase (TNAP) enhances bone healing.
methodsSeven-week-old mice (n = 4-6/group; equal numbers of males and females) underwent maxillary molar extraction and standardized alveolar defect creation. Mice were assigned to sham, FDBA with saline (BGS) or FDBA with mineral-targeted TNAP-Fc-D
conclusionsTNAP-Fc-D PLAIN LANGUAGE SUMMARY: When people lose teeth, keeping enough bone in the jaw is critical for future treatments like dental implants. A common material used to rebuild bone is called freeze-dried bone allograft (FDBA), but it does not always heal quickly or completely. In this study, we tested whether adding a special enzyme called TNAP, which helps build bones naturally, could make FDBA work better. After extracting teeth and creating bone defects in mice, we compared healing between three groups: control (sham), FDBA + saline, and FDBA + engineered TNAP-Fc-D
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