Evidence map›Paper›PMID 41582817›Full record

ArticleCirculation. Genomic and precision medicine2026

Maura L Boerio, Abhijnan Chattopadhyay, Xue-Yan Duan, Aamuktha Karla, Ernesto Calderon Martinez, Amelie Pinard, Andrew K Morse, Darshan Reddy, Sree Dharma, Walter Velasco-Torrez and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Maura L Boerio *Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0000-0003-2000-2815
Abhijnan Chattopadhyay *Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0000-0002-9907-213X
Xue-Yan Duan *Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0009-0006-4778-4975
Aamuktha KarlaDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).
Ernesto Calderon MartinezDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).
Amelie PinardDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0000-0003-1882-5740
Andrew K MorseDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0009-0004-7394-435X
Darshan ReddyDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0009-0006-6573-6694
Sree DharmaDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).
Walter Velasco-TorrezDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).
Julien MarcadierDepartment of Genetics, Alberta Children's Hospital, Calgary, Canada (J.M.).ORCID 0009-0003-2534-8273
Siddharth K PrakashDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0000-0001-6341-9624
Sherene ShalhubDivision of Vascular and Endovascular Surgery, Department of Surgery, Oregon Health & Science University, Portland (S.S.).
Julie De BackerDepartment of Pediatric Cardiology and Center for Medical Genetics, Ghent University Hospital, Belgium (J.D.B.).ORCID 0000-0001-8878-1507
Richmond JeremyFaculty of Medicine and Health, Central Clinical School, University of Sydney, NSW, Australia (R.J.).ORCID 0000-0003-1281-0505
Shaine A MorrisDivision of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston (S.A.M.).ORCID 0000-0002-8056-0934
Anji T YetmanDivision of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha (A.T.Y.).ORCID 0000-0001-6853-578X
Alan C BravermanCardiovascular Division, Washington University, St. Louis, MO (A.C.B.).ORCID 0000-0003-1859-310X
Dianna M MilewiczDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.K.P., D.M.M.).ORCID 0000-0002-7806-0068

Funding

Novel genetic Insight into the molecular pathogenesis of atherosclerosisR01HL146583 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILEWICZ, DIANNA M · 2019 to 2022
$2.6M
NHLBI NIH HHS R01 HL146583
6 · The paper itself

Abstract

background

methodsThe Montalcino Aortic Consortium patient registry was used to identify cases with

resultsEarly onset ASCVD included coronary artery disease, peripheral vascular disease, and atherosclerotic plaques identified by imaging in the arch, descending, or abdominal aorta, along with the celiac, iliac, renal, or vertebral arteries. Twelve

conclusionsAssays assessing the molecular mechanism that leads to early onset ASCVD can identify which

Indexed as

ActinsAtherosclerosisCholesterolHeat Shock Transcription FactorsMyocytes, Smooth MuscleAnimalsFemaleHumansMaleMutation, MissenseACTA2 protein, humanActinsCholesterolHeat Shock Transcription FactorsHSF1 protein, humanactinsatherosclerosischolesterol esterscoronary artery diseaseheat shock transcription factors

Identifiers

PMID41582817
PMCPMC12841933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.