Evidence map›Paper›PMID 41582789›Full record

ArticleACS applied materials & interfaces2026

Ethanol-Guided Hybridization of Extracellular Vesicles with Liquid-Crystalline Lipid Nanoparticles.

Valentina Pacciani, Jacopo Cardellini, Arianna Balestri, Marta Rojas-Rodríguez, Martino Calamai, Mattia Tiboni, Luca Casettari, Catherine E Saunders, Anam A Karimi, Gennaro Sanità and 8 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Valentina PaccianiDepartment of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0009-0000-9931-6256
Jacopo CardelliniDepartment of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, 50019 Florence, Italy.
Arianna BalestriDepartment of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, 50019 Florence, Italy.
Marta Rojas-RodríguezEuropean Laboratory for Non-Linear Spectroscopy, Via Nello Carrara 1, 50019 Sesto Fiorentino, Italy.
Martino CalamaiEuropean Laboratory for Non-Linear Spectroscopy, Via Nello Carrara 1, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-4031-7235
Mattia TiboniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via Ca' le Suore, 2, 61029 Urbino, Italy.ORCID 0000-0002-3953-4937
Luca CasettariDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via Ca' le Suore, 2, 61029 Urbino, Italy.ORCID 0000-0001-6907-8904
Catherine E SaundersSPARTA Biodiscovery, Scale Space White City, 58 Wood Lane, London W12 7RZ, United Kingdom.
Anam A KarimiSPARTA Biodiscovery, Scale Space White City, 58 Wood Lane, London W12 7RZ, United Kingdom.
Gennaro SanitàEYE-Lab, Institute of Applied Sciences and Intelligent Systems, National Research Council, Via Pietro Castellino 111, 80131 Napoli, Italy.
Emanuela EspositoEYE-Lab, Institute of Applied Sciences and Intelligent Systems, National Research Council, Via Pietro Castellino 111, 80131 Napoli, Italy.ORCID 0000-0002-5347-247X
Andrea ZendriniCSGI, Center for Colloid and Surface Science, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0002-3626-0360
Annalisa RadeghieriCSGI, Center for Colloid and Surface Science, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0003-2737-1090
Lucia PaoliniCSGI, Center for Colloid and Surface Science, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0002-4410-5272
Paolo BergeseCSGI, Center for Colloid and Surface Science, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0002-4652-2168
Costanza MontisDepartment of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, 50019 Florence, Italy.
Lucrezia CaselliDepartment of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0001-5293-8816
Debora BertiDepartment of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0001-8967-560X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hybrid nanosystems that integrate biological and synthetic lipid assemblies hold great promise for tailoring nanoscale interfaces with programmable chemical and structural functionality. However, existing approaches to hybridize extracellular vesicles (EVs) with lipid nanoparticles (LNPs) compromise either the EV bioactivity or the native supramolecular organization of synthetic LNPs, undermining structure-dependent functionality. Here, we introduce an ethanol-mediated microfluidic assembly route that enables the

Indexed as

EthanolExtracellular VesiclesLipidsLiquid CrystalsNanoparticlesErythrocytesHEK293 CellsHumansLiposomesScattering, Small AngleEthanolLipid NanoparticlesLipidsLiposomescubosomesextracellular vesicleshybrid lipid nanoparticlesmicrofluidic engineeringred blood cell EVs

Identifiers

PMID41582789
PMCPMC12884453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.