ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Clinical characteristics and prognostic analysis of pediatric acute myeloid leukemia with -7/7q- abnormalities].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo explore the clinical characteristics and prognostic factors of pediatric acute myeloid leukemia (AML) with monosomy 7 (-7) and deletion of the long arm of chromosome 7 (7q-).
methodsA retrospective study was conducted on the clinical data, treatment, and prognosis of children with -7/7q- AML who were admitted to the Department of Pediatrics at Peking University People's Hospital from January 2010 to December 2024.
resultsA total of 869 children with AML who had complete karyotype data were included, of whom 32 (3.7%) had -7/7q- chromosomal abnormalities. There were 20 males and 12 females, and the median age at diagnosis was 6 years. Six children (19%) had isolated -7; 2 (6%) had isolated 7q-; and 24 (75%) had additional chromosomal abnormalities. After induction chemotherapy, complete remission (CR) was achieved in 16 children (50%). At the last follow-up, 15 children (47%) had died and 17 (53%) were alive. The 3-year disease-free survival (DFS) rate was (54.1±0.1)%, and the 3-year overall survival (OS) rate was (52.6±0.1)%. The multivariable analysis showed that hematopoietic stem cell transplantation (HSCT) was an independent prognostic factor for DFS (
conclusionsThe incidence of -7/7q- chromosomal abnormalities in children with AML is 3.7%. Additional chromosomal aberrations are common, and the CR rate after induction chemotherapy is low. HSCT is associated with improved prognosis and survival.
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