ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Clinical characteristics of pediatric patients with acute lymphoblastic leukemia admitted to the pediatric intensive care unit].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate risk factors for pediatric intensive care unit (PICU) admission among children with acute lymphoblastic leukemia (ALL) and risk factors for receipt of life-sustaining therapy (LST) in the PICU.
methodsClinical data of ALL patients treated at the Children's Medical Center of the Second Xiangya Hospital from June 2016 to June 2021 were retrospectively reviewed. Patients were categorized into PICU and non-PICU groups according to PICU admission. Multivariable logistic regression was applied to identify risk factors for PICU admission. The cumulative probability of PICU admission was estimated using Kaplan-Meier curves. PICU patients were further stratified into LST and non-LST groups according to whether LST was received, and multivariable logistic regression was used to identify risk factors for receiving LST.
resultsA total of 200 children with ALL were included; 42 (21.0%) were admitted to the PICU at least once, with 48 total admissions. Multivariable logistic regression analysis showed that hyperleukocytosis at diagnosis and lactate dehydrogenase (LDH) >500 U/L were independent risk factors for PICU admission (both
conclusionsChildren with ALL who have hyperleukocytosis at diagnosis and LDH >500 U/L have a higher risk of PICU admission; respiratory failure is an independent risk factor for receipt of LST among PICU-admitted ALL patients.
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