ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026
A National Analysis of Microscopic Positive Margins in Oropharyngeal Cancer Patients Undergoing Transoral Robotic Surgery.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe objective was to identify clinical variables associated with microscopic positive margins (PMs) during transoral robotic surgery (TORS) for oropharyngeal cancer (OPC) resection, and to explore the association of the receipt of adjuvant treatment with overall survival (OS) in this population. STUDY
designRetrospective cohort analysis.
setting2019 Patient User File of the National Cancer Database.
methodsPatients >18 years of age with OPC were stratified based on margin status. Multivariable logistic regression was used to identify clinical variables associated with PM. Survival analyses were performed using multivariable Cox proportional hazards models. Adjusted odds ratios (aORs) and hazard ratios (aHRs) with associated 95% confidence intervals (CIs) were generated.
resultsIn total, 4294 patients met the criteria. The PM rate was 16.6%. Human papillomavirus (HPV)-negative squamous cell carcinoma (SCCa), salivary gland carcinoma, clinical T category, base of tongue primary site, and treatment at low-volume, nonacademic institutions were independently associated with PM. PMs were associated with increased mortality (aHR 1.67, 95% CI: 1.40-1.99). In patients with PM, but without extranodal extension (ENE), adjuvant radiation therapy (aRT) (aHR 0.29, 95% CI: 0.19-0.45) and adjuvant chemoradiotherapy (aCRT) (aHR 0.31, 95% CI: 0.21-0.45) were associated with an improvement in OS versus surgery alone; however, OS between aRT and aCRT was similar for both HPV-positive and HPV-negative SCCa.
conclusionHistologic type, clinical T category, tumor subsite, and treatment at low-volume, nonacademic institutions were independently associated with TORS PM. aCRT did not confer a survival benefit over aRT in the overall cohort, or in subgroups of HPV-associated or HPV-negative SCCa patients with PM without ENE.
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