ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026
Effects of Aging on Superior Laryngeal Sensory and Motor Function in a Rat Model.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveAging is a risk factor for diminished laryngeal sensation, dysphagia, and aspiration events; however, the mechanisms underlying age-related swallow dysfunction are not well understood. Some of these changes are thought to be mediated through superior laryngeal nerve (SLN) dysfunction. The purpose of this study was to measure the effects of aging on SLN motor and sensory function in a rat model. STUDY
designAnimal study.
settingTertiary-care center.
methodsEvoked response studies were performed by SLN stimulation. Outcome measures included compound motor (CMAP) and sensory nerve action potential (SNAP) measurements recorded from the cricothyroid muscle and the internal branch of the SLN, respectively. Swallow force measurements were recorded by stimulating the SLN and quantifying the hyoid elevation force. Additionally, force and frequency of electrically and tactile-stimulated swallow reflex were analyzed. These measures were collected in adult Sprague-Dawley rats aged 4, 18, and 24 months.
resultsCompared to non-aged rats, advanced age was associated with significantly longer SNAP latency and total duration with a mean difference (95% CI) of 1.23 milliseconds (1.06-1.40) and 2.24 milliseconds (1.89-2.59), respectively. CMAP latency and total duration were also increased by 0.27 milliseconds (0.23-0.31) and 1.5 milliseconds (1.14-1.87), respectively. Advanced age was associated with decreased electrical and tactile-stimulated swallow frequency with a mean difference of 3.3 swallows/10 seconds (95% CI 1.1-5.5) and 2.1 swallows/10 seconds (95% CI 0.71-3.5), respectively.
conclusionAdvanced age was associated with longer SNAP and CMAP duration and decreased swallow frequency. The results suggest delayed nerve conduction as a potential mechanism for age-related swallow dysfunction in our rat model. Our work has implications in humans with the hopes for developing targeted therapies for age-related swallow dysfunction. LEVEL OF EVIDENCE: N/A.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.