Evidence map›Paper›PMID 41582683›Full record

SynthesisInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

Deinfibulation for improving obstetric, neonatal, gynecologic, and sexual health outcomes in women and girls with type III female genital mutilation: A systematic review and meta-analysis.

Babasola Okusanya, Ekpereonne Esu, Nuria Nwachuku, Victoria Adaramoye, Ella Olughu, Komommo Okpebri, Chibuike Meremikwu, Joshua Meremikwu, Francis Iwomi, Martin Meremikwu

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Deinfibulation for improving obstetric, neonatal, gynecologic, and sexual health outcomes in women and girls with type III female genital mutilation: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Babasola OkusanyaDepartment of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.ORCID https://orcid.org/0000-0003-2381-873X
Ekpereonne EsuDepartment of Public Health, University of Calabar, Calabar, Nigeria.
Nuria NwachukuDepartment of Public Health, University of Calabar, Calabar, Nigeria.
Victoria AdaramoyeDepartment of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria.
Ella OlughuCochrane Nigeria, University of Calabar Teaching Hospital, Calabar, Nigeria.
Komommo OkpebriDepartment of Obstetrics and Gynaecology, University of Calabar Teaching Hospital, Calabar, Nigeria.
Chibuike MeremikwuCochrane Nigeria, University of Calabar Teaching Hospital, Calabar, Nigeria.
Joshua MeremikwuCochrane Nigeria, University of Calabar Teaching Hospital, Calabar, Nigeria.
Francis IwomiCross River Health and Demographic Surveillance System, University of Calabar, Calabar, Nigeria.
Martin MeremikwuDepartment of Paediatrics, University of Calabar, Calabar, Nigeria.

Funding

This work received funding from the Government of Norway and the UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), a co-sponsored program executed by the World Health Organization (WHO).
6 · The paper itself

Abstract

backgroundType III female genital mutilation (FGM) is corrected by the scar tissue removal of the vaginal opening, known as deinfibulation.

objectivesTo determine the current evidence on whether deinfibulation leads to improved obstetric, neonatal, gynecologic, and sexual health outcomes. SEARCH STRATEGY: The following databases were searched from inception to May 18, 2023: CINAHL Plus (EBSCOhost), MEDLINE (Ovid), PsycINFO (EBSCOhost), SCOPUS, and Web of Science. SELECTION CRITERIA: Two review authors independently screened the titles and abstracts, extracted data, and performed the risk of bias assessment. DATA COLLECTION AND ANALYSIS: Meta-analysis was conducted with RevMan, and the quality of evidence was assessed using the GRADE approach. MAIN

resultsEight studies with serious risk of bias involving 3166 women were included. Very low-certainty evidence indicates that deinfibulation for women with type III FGM reduced the odds of an emergency cesarean birth (odds ratio [OR] 0.16, 95% confidence interval [CI] 0.06-0.42) and genital tract lacerations (OR 0.48, 95% CI 0.29-0.79) when compared to women with type III FGM without deinfibulation. Reduced odds of an emergency cesarean birth apply when compared to women without FGM (OR 0.59, 95% CI 0.37-0.93). Antepartum deinfibulation, compared to intrapartum deinfibulation, may lead to a reduction in the duration of labor, with little or no difference in the risk of prolonged labor (low-certainty evidence). Antepartum deinfibulation may increase the likelihood of postpartum hemorrhage and cesarean births in pregnant women with type III FGM (low-certainty evidence). We found no studies for inclusion on gynecologic, urologic, and sexual health outcomes for this update.

conclusionsThe evidence of deinfibulation for women with type III FGM is available only for obstetrics outcomes. Larger observational studies in settings where type III FGM is predominantly practiced are required to improve the certainty of the evidence in these findings.

Indexed as

CicatrixCircumcision, FemaleCesarean SectionFemaleHumansInfant, NewbornPregnancySexual Healthdeinfibulationinfibulationtype III FGMtype III FGM/C

Identifiers

PMID41582683
PMCPMC12833633

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.