ArticleACS applied materials & interfaces2026
Structure-Selective Polydopamine Coating on Drug Nanoparticles.
Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polydopamine (PDA) is widely regarded as a universal coating material with substrate-independent adhesion. Here we report the first demonstration of selective PDA coating on small molecule drugs, revealing unexpected structure-dependent behavior that challenges this paradigm. Systematic screening of 30 chemotherapeutic agents in IR783-stabilized nanoparticles (>90% drug loading) showed dramatic coating variations governed by molecular structure rather than conventional hydrophobic or π-π interactions. Using Dragon molecular descriptors and principal component analysis, we developed a predictive decision tree model based on nitrogen content and bonding topology that correctly classified 80% of validation compounds. Coating selectivity correlates primarily with nitrogen percentage and N-C-N motifs, fundamentally expanding the understanding of PDA surface chemistry beyond nonselective adhesion mechanisms. Representative drugs (trametinib, dasatinib) demonstrated that PDA coating significantly improves colloidal stability and reduces aggregation without compromising drug loading or release kinetics.
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