Evidence map›Paper›PMID 41582428›Full record

ReviewAllergy2026

Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms.

E Hamelmann, B Schaub, K Beyer, K Blümchen, M Gerstlauer, M V Kopp, L Lange, S Lau, N Maison, H Ott and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

E HamelmannDepartment of Pediatrics, Children's Center Bethel, University Hospital OWL, University Bielefeld, Bielefeld, Germany.
B SchaubPediatric Allergology, Department of Pediatrics, Dr. Von Hauner Children's Hospital, University Hospital, Munich, Germany.ORCID https://orcid.org/0000-0003-1652-8873
K BeyerDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
K BlümchenDepartment of Pediatrics, Division of Pneumology, Allergology, Gastroenterology and Infectious Diseases, Goethe University, Frankfurt, Germany.
M GerstlauerPaediatric and Adolescent Medicine, Department of Paediatric Pneumology and Allergology, University Medical Center Augsburg, Augsburg, Germany.
M V KoppDepartment of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
L LangeGFO Kliniken Bonn, Bonn, Germany.
S LauDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-5189-4265
N MaisonPediatric Allergology, Department of Pediatrics, Dr. Von Hauner Children's Hospital, University Hospital, Munich, Germany.
H OttSection of Pediatric Dermatology, Munich University Center for Children With Medical and Developmental Complexity, Ludwig-Maximilians-University Hospital, Munich, Germany.
S M SchmidtDepartment of Pediatrics, University Medicine, Greifswald, Germany.
T SpindlerAllergologisch-Pneumologische Ambulanz Pädiatrie Medizincampus Bodensee, Friedrichshafen, Germany.
C Traidl-HoffmannMedical Faculty, Institute of Environmental Medicine and Integrative Health, EMIH, University Augsburg, Augsburg, Germany.ORCID https://orcid.org/0000-0001-5085-5179
C VogelbergDepartment of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtopic diseases-including atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), and asthma-are the most common chronic conditions in childhood and adolescence, affecting up to 30% of the global population. In Germany alone, more than 2.1 million children and adolescents are affected. These conditions frequently coexist and share common genetic, environmental, dietary, and microbial risk factors.

methodsA comprehensive literature review was conducted, and a multidisciplinary Task Force of the German Society for Pediatric Allergology and Environmental Medicine (GPA) and the German Society for Allergology and Clinical Immunology (DGAKI) developed consensus-based algorithms for early risk assessment and recognition of allergies in children in already existing preventive medical check-ups. The approach emphasizes stepwise risk assessment, including family history, environmental exposures, and early clinical signs such as recurrent wheezing.

resultsFor children identified as at risk for or with early clinical signs of atopy, targeted diagnostic steps are recommended that follow the national/international guidelines for the management of the suspected atopic disease. This may include general and specific recommendations for nutrition, measurement of specific sensitization and selected biomarkers, if indicated and recommended by the guidelines. Routine allergy testing in asymptomatic children is not recommended. The algorithms are designed to be embedded into routine pediatric check-ups, enabling systematic and early identification of children at increased risk or with early clinical signs of atopic diseases. Early recognition and management can reduce disease severity, improve quality of life, and decrease healthcare costs.

conclusionStructured programs for early risk assessment and recognition of allergies in children are currently lacking but can provide substantial clinical and economic benefits. Integration into routine pediatric preventive examinations, supported by standardization, interdisciplinary collaboration, and sustainable funding, offers a promising strategy to improve long-term outcomes for affected children and their families.

Indexed as

AlgorithmsHypersensitivityAdolescentChildEarly DiagnosisHumansRisk AssessmentRisk Factorsatopic diseaseschildrenearly allergy recognitionpredictive markerspreventionrisk assessmentrisk factors

Identifiers

PMID41582428
PMCPMC13256288

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.