ArticleEndocrine, metabolic & immune disorders drug targets2026
Decoding Diabetes: Hub Genes as Pivotal Players in Cardiomyopathy and Kidney Disease.
Article in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDiabetes mellitus (DM) induces systemic vascular dysfunction and leads to life-threatening complications, including diabetic cardiomyopathy (DCM) and diabetic kidney disease (DKD), whose shared mechanisms remain elusive. In this study, we performed an indepth bioinformatics analysis to identify shared therapeutic targets and key molecular players in DKD and DCM.
methodsIntegrated computational and experimental approaches were employed. Bioinformatics analysis of GEO datasets (GSE30122 and GSE197850) identified differentially expressed genes (DEGs). Hub genes were extracted via protein-protein interaction networks and functional enrichment.
resultsWe identified 48 common DEGs ( DISCUSSION: Our study is one of the first to simultaneously investigate the molecular underpinnings of DKD and DCM by integrating bioinformatics data with experimental validation. Meanwhile, the relatively small sample sizes may limit the statistical power and generalizability of the identified DEGs.
conclusionThis study uncovers novel shared mechanisms between DCM and DKD, providing a framework for dual-organ protective therapies to advance the management of diabetic complications.
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