Clinical correlation between plasma biomarker levels and post-transplant complications of allogeneic hematopoietic stem cell transplantation in children.

Wei Yang, Maoquan Qin, Chenguang Jia, Bin Wang, Guanghua Zhu

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Article in International journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Wei YangHematology Center (Stem Cell Transplantation Department), National Key Discipline of Pediatrics (Capital Medical University), National Key Clinical Discipline of Pediatric Hematology, National Center for Children's Health, Beijing, 100045, China.

Maoquan QinHematology Center (Stem Cell Transplantation Department), National Key Discipline of Pediatrics (Capital Medical University), National Key Clinical Discipline of Pediatric Hematology, National Center for Children's Health, Beijing, 100045, China.

Chenguang JiaHematology Center (Stem Cell Transplantation Department), National Key Discipline of Pediatrics (Capital Medical University), National Key Clinical Discipline of Pediatric Hematology, National Center for Children's Health, Beijing, 100045, China.

Bin WangHematology Center (Stem Cell Transplantation Department), National Key Discipline of Pediatrics (Capital Medical University), National Key Clinical Discipline of Pediatric Hematology, National Center for Children's Health, Beijing, 100045, China.

Guanghua ZhuHematology Center (Stem Cell Transplantation Department), National Key Discipline of Pediatrics (Capital Medical University), National Key Clinical Discipline of Pediatric Hematology, National Center for Children's Health, Beijing, 100045, China. guangh.zhu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigated the correlation between plasma biomarker levels and post-transplant complications of allo-HSCT in children. The biomarkers analyzed were sST2, REG3α, TNFR1, IL-6, and IL-8.

methodsFrom January 1, 2019 to October 30, 2024, specimens from 157 patients were collected at aGVHD onset or when aGVHD was clinically presumed to be likely to occur.

resultsPatients with aGVHD and intestinal aGVHD had significantly elevated sST2 levels. Patients with grade III/IV aGVHD had significantly higher sST2 and REG3α levels than patients with grade I/II aGVHD. OS and NRM differed significantly between patients with high sST2 and REG3α indexes (sST2 ≥ 124,090 pg/ml and REG3α ≥ 17,176 pg/ml) and those with low sST2 and REG3α indexes (P < 0.05). Univariate logistic regression analysis indicated that aGVHD, SOS, and TA-TMA were correlated with elevated sST2 and REG3α levels. Multivariate logistic regression analysis indicated that grade III/IV aGVHD was significantly associated with elevated sST2 and REG3α levels (each P = 0.003).

conclusionsElevated sST2 and REG3α can reflect the occurrence and severity of aGVHD. Acute GVHD, SOS, and TA-TMA can all lead to fluctuations in sST2 and REG3α levels, and warrant further study.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationPostoperative ComplicationsAdolescentBiomarkersChildChild, PreschoolFemaleHumansInfantInterleukin-1 Receptor-Like 1 ProteinMalePancreatitis-Associated ProteinsTransplantation, HomologousBiomarkersIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinPancreatitis-Associated ProteinsREG3A protein, humanAllogeneic hematopoietic stem cell transplantationPediatricPlasma biomarkersPost-transplant complications

Identifiers

PMID41582285

DOI10.1007/s12185-026-04162-w

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.