ArticleMikrochimica acta2026
Rapid and ultra-low detection of cancer biomarker miRNA-133a-3p via AC electrokinetics-integrated capacitive sensing.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
MicroRNAs (miRNAs) are promising biomarkers for early cancer detection, but their low abundance and matrix interference continue to limit rapid, point-of-care (POC) assays. Here, we report a rapid, sensitive, and label-free biosensing platform for the detection of miRNA-133a-3p, a tumor-suppressive biomarker implicated in various cancers. The sensor operates on a non-faradaic capacitive principle, utilizing gold-plated printed-circuit-board interdigitated electrodes functionalized with thiolated single-stranded DNA capture probes. Alternating current electrokinetic (ACEK) effects are integrated with capacitive readout to achieve a single-step operation that enhances target transport to the interface, accelerates hybridization, and amplifies the capacitance transient. Assay conditions were optimized to achieve a linear dynamic range from 1 fM to 1 pM with a high sensitivity of 2.44%/min per decade and a limit of detection (LOD) as low as 0.56 fM in a standard buffer. High specificity was confirmed through selectivity tests against non-complementary miRNAs. For serum analysis, only a simple 1:100 dilution is required prior to measurement, yielding a LOD of 0.74 fM in diluted serum (equivalent to 74 fM in neat serum). This portable and cost-effective ACEK-capacitive platform enables fast and selective miRNA detection in complex matrices with minimal sample preparation.
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