Resting-state brain function and its modulation by intranasal oxytocin in antisocial personality disorder with and without psychopathy.

Julia Griem, Daniel Martins, John Tully, Declan Murphy, Yannis Paloyelis, Nigel Blackwood

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Julia GriemDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK. julia.griem@kcl.ac.uk.

Daniel MartinsDepartment of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience, King's College London, Centre for Neuroimaging Sciences, De Crespigny Park, London, SE5 8AB, UK.

John TullyAcademic Unit of Mental Health and Clinical Neurosciences, School of Medicine, Institute of Mental Health, University of Nottingham, University of Nottingham Innovation Park, Triumph Road, Nottingham, NG7 2TU, UK.

Declan MurphyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.

Yannis PaloyelisDepartment of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience, King's College London, Centre for Neuroimaging Sciences, De Crespigny Park, London, SE5 8AB, UK.

Nigel BlackwoodDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.

Funding

Economic and Social Research Council ES/K009400/1Wellcome TrustWellcome Trust 200099/S/15/S

6 · The paper itself

Abstract

Behavioural, structural, and functional neuroimaging differences exist between individuals with antisocial personality disorder with (ASPD + P) or without psychopathy (ASPD-P). However, the aetiological mechanisms underpinning such differences remain unclear, hindering treatment development. Intranasal oxytocin (OT) has shown modulatory effects on social brain function in healthy and antisocial populations. We investigated the effects of OT on resting-state brain function in individuals with violent offending histories with ASPD+/-P using arterial spin labelling to measure regional cerebral blood flow (rCBF). A double-blind, placebo-controlled, crossover design was employed with males with ASPD (ASPD + P: N = 17, ASPD-P: N = 14) and healthy male non-offenders (N = 22). Both ASPD subtypes exhibited reduced rCBF in frontotemporal regions compared to non-offenders. Individuals with ASPD + P showed significantly greater rCBF increases in posterior default mode network regions compared to individuals with ASPD-P. OT administration selectively decreased rCBF in the left basal ganglia of the ASPD-P group, an effect not observed in ASPD + P or non-offender groups. These findings highlight functional brain differences between individuals with ASPD + P and ASPD-P at rest and demonstrate oxytocin's differential impact on resting-state measures. Further understanding of the origins of these neurobiological differences could inform targeted therapeutic strategies for individuals with ASPD with and without psychopathy.

Indexed as

Antisocial Personality DisorderBrainOxytocinAdministration, IntranasalAdultCerebrovascular CirculationCross-Over StudiesDouble-Blind MethodHumansMagnetic Resonance ImagingMaleRestYoung AdultOxytocinAntisocial personality disorderOxytocinPerfusionPsychopathyRCBFResting-state brain function

Identifiers

PMID41582219

DOI10.1038/s41598-026-36661-5

PMCPMC12905299

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.