Trial reportBMC oral health2026
Rapid maxillary expansion related sutural and dentoalveolar changes provoke early-term oxidative stress.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06937775 (Rapid Maxillary Expansion Related Sutural and Dentoalveolar Changes Provoke Salivary Oxidative Stress), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Rapid Maxillary Expansion Related Sutural and Dentoalveolar Changes Provoke Salivary Oxidative Stress: A Biochemical Study
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of oxidative stress-related cellular activity plays an important role in the bone healing process and dentoalveolar resorption. The aim of this study was to investigate the effects of rapid maxillary expansion on local and systemic oxidative stress levels.
methodsThirty-five volunteer patients (17 females and 18 males) who needed rapid maxillary expansion were included in the study. Serum and unstimulated saliva samples were collected from each patient during four different periods: a week before the treatment (T0), the first day when sutural opening was detected clinically and radiographically (T1), the last day of the active expansion period (T2), and after the completion of a 3-month retention period (T3). To evaluate the patients’ periodontal status, plaque index, gingival index and probing pocket depth scores were recorded for each period. 8-hydroxydeoxyguanosine (8-OHdG), total oxidative status (TOS), total antioxidant status (TAS) and oxidative stress index (TOS/TAS: OSI) biomarkers were evaluated with ELISA and spectrophotometric methods to determine the local and systemic oxidative stress levels.
resultsThere were no statistically significant differences in the clinical periodontal parameters between the four measurement periods (p > 0.05). In the T1 period, only the salivary levels of the 8-OHdG (T1-T0; p:0.001, T2-T1; p:0.030, T3-T1; p:0.045), TOS (T1-T0; p < 0.001, T2-T1; p < 0.001, T3-T1; p < 0.001) and OSI (T1-T0; p < 0.001, T3-T1; p < 0.001) were statistically significantly higher when compared to the other periods. On the other hand, both the serum and salivary TAS levels there were not statistically significantly different between the periods (p > 0.05).
conclusionPeriodontal and skeletal changes associated with rapid maxillary expansion cause an increase in only salivary oxidative stress levels, especially during the initial sutural opening period (5–7 days).
trial registrationClinical Trial Number is NCT06937775. It was recorded retrospectively (Record date 21/04/25).
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