Trial reportScientific reports2026
Effects of immersive virtual reality and adaptive cognitive training on cognition and function in parkinson's disease mild cognitive impairment: a randomized clinical trial.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05769972 (Randomized, Single-blind Clinical Trial to Evaluate the Efficacy of Cognitive Rehabilitation Using Inmersive Virtual Reality and Computer-based Cognitive Stimulation Versus Music Therapy on Cognitive Impairment Associated With Movement Disorders), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Single-blind Clinical Trial to Evaluate the Efficacy of Cognitive Rehabilitation Using Inmersive Virtual Reality and Computer-based Cognitive Stimulation Versus Music Therapy on Cognitive Impairment Associated With Movement Disorders
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The impact of virtual reality exercise on motor function, balance and gait function, and cognitive function in stroke patients: an umbrella review of systematic reviews and meta-analyses.Frontiers in sports and active living · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment is a common non-motor feature of Parkinson's disease with no established treatments. Non-pharmacological interventions may promote neural plasticity and enhance cognition. However, high-quality trials are needed to confirm their efficacy and underlying mechanisms. We conducted a 24-week, single-center, randomized, single-blind clinical trial to investigate the efficacy of Immersive Virtual Reality (IVR) and adaptive Computerized Cognitive Training (CCT) for mild cognitive impairment in Parkinson's disease (PD-MCI) in 51 individuals. Participants were randomized into an executive function-focused IVR intervention (n = 19) or a multidomain CCT intervention (n = 17). A standard of care (SoC; n = 15) group was also involved. Weekly 45-minute sessions were conducted. Baseline and post-intervention assessments included global cognition, functional, and neuropsychiatric measures, digital biomarker performance metrics, and structural and functional neuroimaging. IVR and CCT groups showed significant improvements in primary and secondary cognitive endpoints. Compared to the SoC group, the IVR group showed an improvement in the trajectory of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), cognitive-functional dependency measures (PD-CFRS) and apathy at week 24. The CCT group showed a positive trend in the PD-CRS scores and a significant improvement in PD-CFRS. Digital biomarkers showed greater efficiency performance over time. Functional neuroimaging analyses revealed connectivity changes in large-scale cognitive networks in both intervention groups. Both interventions significantly improved cognition and functional outcomes in PD-MCI compared to SoC. Technology-based cognitive interventions offer a promising, adaptive, and personalized approach to managing PD-MCI. Registry: ClinicalTrials.gov, TRN: NCT05769972, Registration date: 03 March 2023.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.