ArticleBMC cancer2026
Uterine tumors with sex cord-like elements: a clinicopathologic study of 19 cases.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare uterine tumors predominantly made up of sex cord-like elements. However, sex cord-like elements are also concomitant components in a variety of non-UTROSCTs, and the differences between these two types of sex cord-like elements have not yet been elucidated. Therefore, in this study, we aimed to elucidate the clinicopathological features of UTROSCTs and non-UTROSCTs.
methodsNine UTROSCTs, seven low-grade endometrial stromal sarcomas, two adenosarcomas (AS), and one corded and hyalinized endometrioid carcinoma were retrospectively analyzed. Immunohistochemical expression of calretinin, α-inhibin, CD56, Melan A, CD99, and steroidogenic factor-1 (SF-1) was analyzed in the sex cord-like elements of these tumors.
resultsCalretinin, Melan A, and SF-1 were exclusively positive in UTROSCTs and AS, and the immunohistochemical profiles of the sex cord-like elements between these two tumors were most similar. Calretinin was the most specific marker for distinguishing between UTROSCTs and non-UTROSCTs.
conclusionsOur findings revealed the immunohistochemical features of sex cord-like elements in primary uterine tumors and indicated their potential significance in the differential diagnosis of UTROSCTs and non-UTROSCTs.
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