ArticleThe Journal of veterinary medical science2026
Successful treatment of ibuprofen intoxication using hemoperfusion with porous polymeric adsorbents in a toy poodle.
Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
A 6-month-old female toy poodle, weighing 2.15 kg, presented with acute vomiting and lethargy after ingesting ibuprofen. Hemoperfusion was performed using an extracorporeal blood purification cartridge, comprising polystyrene-divinylbenzene copolymer beads, connected to a hemodialysis platform as a pre-dialyzer. Serum ibuprofen concentration, measured using high-performance liquid chromatography, was 61.9 mg/L before therapy. The ibuprofen concentrations gradually decreased, reaching 20.5 mg/L after 2 hr (66.8% reduction; half-life of 1.4 hr). The dog showed significant improvement in vitality and recovered fully without further extracorporeal treatment. This case is the first documented instance of successfully treating ibuprofen intoxication in a small dog using hemoperfusion with a blood purification cartridge specifically designed for small animals.
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