Evidence map›Paper›PMID 41581903›Full record

ArticleThe Journal of veterinary medical science2026

Phenotypic impact on coat color and uterine development in mice carrying a missense mutation associated with bovine White Heifer Disease.

Yinga Wu, Marie Sekiguchi, Yoko Nakadaira, Dai Ishiyama, Fumie Magata, Wataru Fujii, Shigeru Kyuwa, Fuko Matsuda, Shigeru Kakuta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yinga WuLaboratory of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Marie SekiguchiLaboratory of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Yoko NakadairaLaboratory of Theriogenology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Dai IshiyamaLaboratory of Theriogenology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Fumie MagataLaboratory of Theriogenology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Wataru FujiiLaboratory of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Shigeru KyuwaLaboratory of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Fuko MatsudaLaboratory of Theriogenology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Shigeru KakutaLaboratory of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White Heifer Disease (WHD) is a congenital reproductive abnormality, especially in white female offspring in certain breeds of cattle like Belgian Blue. The roan locus was reported to affect coat color and fertility. It was suggested that a missense mutation (Ala218Asp) in the transmembrane domain of Kit ligand (KITL) gene was responsible for WHD. Here we generated two types of knock-in (KI) mice to reproduce the missense KITL mutation using pigmented agouti ICR mice. KI mice carrying compound mutations mimicking bovine transmembrane domain showed moderate coat color change, but single missense mutation KI did not. None of them exhibited uterine abnormalities, suggesting that localized gene modification may not fully affect murine KITL function.

Indexed as

Cattle DiseasesHair ColorMutation, MissenseUterusAnimalsCattleFemaleGene Knock-In TechniquesMicePhenotypebovine disease modelcoat colorKit ligandroanWhite Heifer Disease

Identifiers

PMID41581903
PMCPMC13062579

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.