ArticleMolecular & cellular proteomics : MCP2026
Deciphering Stiffness-Driven Changes in Colorectal Cancer by Proteomics.
Article in Molecular & cellular proteomics : MCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Quantitative Analysis of Cytoplasmic Viscosity in Colorectal Cancer Cells by Differential Dynamic Microscopy of Genetically Encoded Nanoparticles.Chemical & biomedical imaging · 2026Article
- Modular dual-channel 3D microscopy for resolving fast nanoscale dynamics in soft matter.Nanoscale advances · 2026Article
- Protocol for synthesis and mechanical characterization of polyacrylamide hydrogels of varying stiffness for cell culture applications.STAR protocols · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Tumor stiffening plays a pivotal role in cancer progression. Increased tumor stiffness, resulting from interactions between cancer cells and their surrounding microenvironment, alters the tumor's mechanical properties and significantly impacts cancer growth and metastasis, the primary cause of cancer-related death. Despite the importance of tumor stiffness, systematic studies exploring its effect on protein dysregulation are limited. In this study, focused on colorectal cancer, we show by in-depth proteomics that matrix stiffness significantly alters the expression of secreted proteins, while intracellular protein levels remain largely unaffected. Functional assays reveal that the changes observed by proteomics in the secretome, driven by matrix stiffness, enhance cell migration, angiogenesis, and matrix remodeling, which collectively would contribute to a more aggressive cancer phenotype in a real scenario. Our findings emphasize the critical role of matrix stiffness in driving colorectal cancer progression through changes in the secretome, offering valuable insights for the development of biomechanical cancer therapies.
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Registered trials
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