Trial reportJournal of the National Cancer Institute2026
EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial.
Trial report in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05322460 (A Web-based Tailored Intervention to Improve the Quality of Life of Long-term Breast Cancer Survivors. A Randomized Controlled Trial), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Web-based Tailored Intervention to Improve the Quality of Life of Long-term Breast Cancer Survivors. A Randomized Controlled Trial
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
backgroundDigital health interventions have shown promise for improving quality of life, especially in the short term after treatment. However, evidence regarding long-term breast cancer survivors (LT-BCSs; disease free >5 years) remains limited. This study aimed to evaluate the effectiveness of an eHealth intervention targeting health promotion and late sequelae management to improve LT-BCSs' quality of life.
methodsIn a randomized controlled clinical trial, 201 LT-BCSs (mean = 11 years posttreatment) were randomly assigned to an intervention group (n = 102) using the CUMACA-M mobile application with specific health advice and recommendations for LT-BCSs, or a control group (n = 99) receiving usual care. Quality of life was measured with the Quality of Life-Cancer Survivors (QOL-CS) scale at baseline and after 3 months. Analyses followed an intention-to-treat approach using t tests, nonparametric tests, and effect sizes.
resultsAt 3 months, no statistically or clinically significant differences between the groups in the overall quality of life score (QOL-CS) were found (difference-in-differences = 0.11; 95% confidence interval = -0.10 to 0.32; P = .303). In the intervention group, a small intragroup decrease in spiritual well-being was observed (-0.25; -0.49 to -0.02), of uncertain clinical significance; no significant differences between groups were detected.
conclusionsThis eHealth intervention did not improve the quality of life of LT-BCSs, suggesting that more personalized, interactive, or professionally supported strategies may be needed. Future research should evaluate the long-term outcomes and effectiveness of hybrid or personalized digital strategies in this population.
trial registrationClinicalTrials.gov NCT05322460; https://clinicaltrials.gov/study/NCT05322460.
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