Evidence map›Paper›PMID 41581199›Full record

SynthesisBrain and behavior2026

Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization.

Ran Bi, Weimin Zhao, Jiaoxuan Li, Songji Han, Haotian Qi, Jian Liu, Jinpu Wu, Shengxian Xu, Zhongda Sun, Zhenru Liu

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ran BiChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.ORCID https://orcid.org/0009-0006-6658-4098
Weimin ZhaoChangchun University of Traditional Chinese Medicine Affiliated Hospital, Changchun, Jilin Province, China.
Jiaoxuan LiChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Songji HanChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Haotian QiChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Jian LiuChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.ORCID https://orcid.org/0009-0000-0012-0828
Jinpu WuChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Shengxian XuChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Zhongda SunChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Zhenru LiuChangchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGiven inconsistent evidence regarding the migraine-Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship.

methodsGWAS summary statistics for migraine and Alzheimer's disease were acquired from the IEU Open GWAS repository. We implemented a multi-stage MR framework comprising (1) univariate analysis, (2) independent replication, (3) multivariable MR, (4) meta-analysis to evaluate migraine-AD causality.

resultsUnivariate results showed OR = 13.43, 95% CI: 2.86-63.16, P < 0.01; replication Mendelian randomization results were OR = 12.64, 2.89-55.38, P < 0.01 with OR = 1.13, 95% CI: 1.06-1.21, P < 0.01, meta-analysis results were OR = 1.14, 95% CI: 1.07- 1.22, P < 0.01. Multivariate Mendelian randomization results were OR = 18.90, 95% CI: 1.69-210.88, P < 0.01.

conclusionConsidering the observed epidemiological correlations and shared pathophysiological mechanisms between migraine and Alzheimer's disease (AD), we propose that chronic migraine may increase the susceptibility to AD through complex biological interactions. This hypothesis is reinforced by our Mendelian randomization (MR) findings, which support a causal relationship. Therefore, early and effective intervention in migraine management could serve as a promising strategy to mitigate the future risk of AD onset.

Indexed as

Alzheimer DiseaseMendelian Randomization AnalysisMigraine DisordersGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideAlzheimer's diseaseMendelian randomizationmigraine

Identifiers

PMID41581199
PMCPMC12832092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.