ArticleCell reports2026
A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.
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Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- A hypothalamic circuit links hunger to mesolimbic dopamine to drive feeding.bioRxiv : the preprint server for biology · 2026Article
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Article
- A Multimodal Imaging Pipeline for the Discovery of Molecular Markers of Cellular Neighborhoods.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
19 authors.
Yuxi LiDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Trevor C ButlerDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Stefano NardoneDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Christopher L JacobsDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Amelia M DouglassDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Joseph C MadaraDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Miriam C McDonoughDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Jenkang TaoDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Elijah D LowensteinDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Luhong WangDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Deepti PantDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Samuel J WalkerDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Annette WangDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Harini SrinivasanDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Zongfang YangDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
John N CampbellDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Linus T TsaiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: ltsai@bidmc.harvard.edu.
Bradford B LowellDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Program in Neuroscience, Harvard Medical School, Boston, MA, USA. Electronic address: blowell@bidmc.harvard.edu.
Jon M ReschDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: jon-resch@uiowa.edu.
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S · 1992 to 2021
$25.0MThe routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MINTEGRATED ENDOCRINE &METABOLIC RESEARCH TRAININGT32DK007516 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BARBARA B. KAHN · 1986 to 2026
$6.8MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron S Leong · 2023 to 2026
$5.4MThe role of interferon regulatory factors in tanycytes during HFD-induced inflammation, obesity and glucose dysregulationR01DK128406 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Linus Tzu-Yen Tsai · 2022 to 2026
$2.7MFeedforward Activation of AgRP Neurons and HungerR01DK134427 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2023 to 2026
$2.0MPredoctoral Training in the Pharmacological SciencesT32GM144636 · NIGMS · UNIVERSITY OF IOWA · PI David L. Roman, STEFAN STRACK · 2022 to 2026
$1.9MNTSHSD2 neuron activity: regulation by aldosterone and afferent control”R01NS141072 · NINDS · UNIVERSITY OF IOWA · PI Jon Resch · 2025 to 2026
$924kCentral Regulation of Sodium Appetite via Synergistic Action of RAAS-sensitive NeuronsR00HL144923 · NHLBI · UNIVERSITY OF IOWA · PI RESCH, JON · 2021 to 2023
$747kCentral regulation of sodium appetite via synergistic action of RAAS-sensitive neuronsK99HL144923 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RESCH, JON · 2019 to 2020
$332kAmerican Heart Association-American Stroke Association 935362NHLBI NIH HHS F31 HL170784NHLBI NIH HHS K99 HL144923NHLBI NIH HHS R00 HL144923NIDDK NIH HHS F32 DK103387NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK128406NIDDK NIH HHS R01 DK134427NIDDK NIH HHS T32 DK007516NIGMS NIH HHS T32 GM144636NINDS NIH HHS R01 NS141072
Abstract
The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1
Indexed as
Paraventricular Hypothalamic NucleusTranscriptomeAnimalsBasic Helix-Loop-Helix ProteinsGABAergic NeuronsMaleMiceMice, Inbred C57BLNeuronsRepressor ProteinsBasic Helix-Loop-Helix ProteinsRepressor ProteinsSim1 protein, mouseBrs3CP: neurosciencehungerMc4rparabrachialparaventricular hypothalamussatietysingle-cell RNA-seqspatial transcriptomicsspinal cordsympathetic nervous system
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.